Molecular Microbiology and Microbial Pathogenesis

Program affiliation
Biomedical Informatics and Data Science
Computational and Systems Biology
Molecular Microbiology and Microbial Pathogenesis
Cancer Biology

Research summary
Novel genetic, microbial, and lifestyle risk factors for lung and gastrointestinal cancers leveraging large-scale clinical and population-based cohorts with deep genomic and phenotypic data

Key words
Systems and translational cancer epidemiology, microbiome, inflammation and immune-metabolic networks

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Plant and Microbial Biosciences
Biochemistry Biophysics and Structural Biology
Molecular Genetics and Genomics

Research summary
Genetics and virulence of the pathogenetic streptococci

Key words
bacteriology, gene expression, inflammation, microbial pathogenesis, toxin

Program affiliation
Molecular Genetics and Genomics
Molecular Microbiology and Microbial Pathogenesis
Developmental Regenerative and Stem Cell Biology

Research summary
Genetic and epigenetic regulation of developmentally programmed DNA rearrangements of Tetrahymena

Key words
chromatin structure, development, DNA, genome rearrangements, RNA interference, transcription

Program affiliation
Cancer Biology
Molecular Microbiology and Microbial Pathogenesis
Immunology

Research summary
Tryptophan metabolism and probiotic bacteria as modifiers of intestinal cancer and inflammation

Key words
tryptophan metabolism, intestinal inflammation, colitis associated cancer, colon cancer, mucositis, tryptophan, crohn, colitis, inflammatory bowel disease, radiation enteritis

Program affiliation
Immunology
Molecular Microbiology and Microbial Pathogenesis
Neurosciences

Research summary
Innate immune responses in infections, autoimmunity and tumors

Key words
immunology, inflammation, dendritic cells, lymphocytes, receptors, virus, gut, mucosa

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Molecular Genetics and Genomics
Immunology
Developmental Regenerative and Stem Cell Biology

Research summary
To address the central mandate of gene therapy we engineer adenovirus tropism to allow the achievement of effective gene delivery

Key words
Adenovirus, virotherapy, virus, cancer, gene therapy, vaccine

Program affiliation
Biochemistry Biophysics and Structural Biology
Neurosciences
Molecular Microbiology and Microbial Pathogenesis
Molecular Cell Biology

Research summary
My lab aims to establish the fundamental principles of intracellular physical chemistry and electrochemical functions of macromolecular complexes, and design synthetic proteins as therapeutics for condensate-dependent diseases.

Key words
molecular biology; physical chemistry; biochemistry; biophysics; synthetic biology; electrochemistry; phase transition; condensates

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Computational and Systems Biology
Molecular Genetics and Genomics
Ecology and Evolutionary Biology

Research summary
(1) Dynamics, ecology, and evolution of antibiotic resistance, (2) Engineering enhanced probiotics to treat GI disorders, (3) Engineering microbial biofuel catalysts

Key words
anibiotic resistance, synthetic biology, bioenergy, human microbiome, metagenomics, microbial ecology and biodiversity

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Immunology

Research summary
Innate and Adaptive Host Immunity to Viral Infections

Key words
virology, microbial pathogenesis, immunology

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Immunology
Molecular Cell Biology

Research summary
Understanding how rotavirus (RV), an important enteric viral pathogen, interacts with the host innate immune system in the small intestine

Key words