Molecular Microbiology and Microbial Pathogenesis
Eric Galburt, PhD
Professor
- Email: egalburt@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Microbiology and Microbial Pathogenesis
Research summary
Biophysical studies of transcription initiation in Eukaryotes and Mycobacterial tuberculosis
Key words
biophysics, kinetics, optical and magnetic trapping, transcription, fluorescence
Aliereza Ghanbarpour, PhD
Assistant Professor
- Email: alirezag@wustl.edu
Program affiliation
Biochemistry, Biophysics, and Structural Biology
Molecular Cell Biology
Molecular Microbiology and Microbial Pathogenesis
Research summary
Our research focuses on unraveling the molecular mechanisms underlying substrate specificity and degradation by AAA proteolytic machines and their associated adaptor proteins, utilizing structural biology, biochemistry, and cellular assays in both bacteria and human mitochondria.
Key words
AAA proteases, cryo-EM, biochemistry, mass spectrometry, structural biology, microbiology, mitochondria
Nicole Gilbert, PhD
Assistant Professor
- Email: gilbert@wustl.edu
Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Research summary
We study host-microbe and microbe-microbe interactions in the female reproductive and urinary tracts, with a focus on the vaginal microbiome and UTIs
Key words
urinary tract infection, vaginal microbiome, women's health, host-pathogen interactions, mucosal immunology
Daniel Goldberg, MD, PhD
Professor
- Email: dgoldberg@wustl.edu
Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Research summary
Biochemistry of malaria
Key words
biochemistry, metabolism, parasitology, malaria, protease, heme, aspartic
Jeffrey Gordon, MD
Dr. Robert J. Glaser Distinguished University Professor
- Email: jgordon@wustl.edu
Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Computational and Systems Biology
Molecular Cell Biology
Plant and Microbial Biosciences
Research summary
Role of the human gut microbiome in health and disease, notably childhood undernutrition and obesity
Key words
Gut microbiome; systems biology; postnatal development; childhood malnutrition; global health; gnotobiotic animal models; metabolic regulation; food webs; gut-brain axis; gut barrier/immune function; microbiome-targeted therapeutics
Scott Handley, PhD
Professor
- Email: shandley@wustl.edu
Program affiliation
Computational and Systems Biology
Molecular Microbiology and Microbial Pathogenesis
Immunology
Research summary
Key words
Jeffrey Haspel, MD, PhD
Associate Professor
- Email: jhaspel@wustl.edu
Program affiliation
Molecular Cell Biology
Molecular Microbiology and Microbial Pathogenesis
Biochemistry Biophysics and Structural Biology
Research summary
Understand the impact of time as a biological variable in the development of critical illness such as sepsis, respiratory failure and chronic inflammatory lung disease
Key words
Jeffrey Henderson, MD, PhD
Associate Professor
- Email: hendersonj@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Microbiology and Microbial Pathogenesis
Research summary
Biochemical interactions between humans and bacteria in health and disease
Key words
bacterial pathogenesis, host-pathogen interactions, iron, mass spectrometry, medicinal chemistry, metabolomics
Michael Holtzman, MD
Selma and Herman Seldin Professor
- Email: mjholtzman@wustl.edu
Program affiliation
Immunology
Molecular Microbiology and Microbial Pathogenesis
Molecular Cell Biology
Research summary
Pathogenesis and new therapeutics for viral infection and post-viral disease
Key words
innate immunity, macrophages, innate lymphocytes, dendritic cells, epithelial cells, interferon signal transduction, paramyxoviruses, picornaviruses, asthma, drug discovery
Henry Huang, PhD
Associate Professor
- Email: huang@wustl.edu
Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Research summary
Molecular biology of Sindbis virus; antiviral drug design; monocyte differentiation
Key words
RNA, virology, genome analysis, evolution, antiviral targeting