Molecular Microbiology and Microbial Pathogenesis

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology

Research summary
Biochemistry of malaria

Key words
biochemistry, metabolism, parasitology, malaria, protease, heme, aspartic

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Computational and Systems Biology
Molecular Cell Biology
Plant and Microbial Biosciences

Research summary
Role of the human gut microbiome in health and disease, notably childhood undernutrition and obesity

Key words
Gut microbiome; systems biology; postnatal development; childhood malnutrition; global health; gnotobiotic animal models; metabolic regulation; food webs; gut-brain axis; gut barrier/immune function; microbiome-targeted therapeutics

Program affiliation
Computational and Systems Biology
Molecular Microbiology and Microbial Pathogenesis
Immunology

Research summary

Key words

Program affiliation
Molecular Cell Biology
Molecular Microbiology and Microbial Pathogenesis
Biochemistry Biophysics and Structural Biology

Research summary
Understand the impact of time as a biological variable in the development of critical illness such as sepsis, respiratory failure and chronic inflammatory lung disease

Key words

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Microbiology and Microbial Pathogenesis

Research summary
Biochemical interactions between humans and bacteria in health and disease

Key words
bacterial pathogenesis, host-pathogen interactions, iron, mass spectrometry, medicinal chemistry, metabolomics

Program affiliation
Immunology
Molecular Microbiology and Microbial Pathogenesis
Molecular Cell Biology

Research summary
New drugs for post-viral and related types of disease

Key words
drug discovery, innate immunity, epithelial stem cells, viruses, respiratory airway disease

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Plant and Microbial Biosciences
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology

Research summary
Interdisciplinary approach combining genetics, genomics, biochemistry, structural biology, high-resolution imaging, animal models, clinical studies and combinatorial chemistry to determine key aspects of bacterial pathogenesis and apply our knowledge to development of new therapeutics.

Key words
antibiotic-sparing therapeutics, host-pathogen interactions, bacterial pathogenesis, drug and vaccine development, multi-drug resistant E. coli, MRSA, Enterococcus, Acinetobacter, Klebsiella, urinary tract infections (UTI)

Program affiliation
Molecular Microbiology and Microbial Pathogenesis

Research summary
Host-pathogen interactions in E. coli urinary tract infections and sepsis

Key words
bacterial pathogenesis, Escherichia coli, host-pathogen interactions, innate immunity, novel therapeutics, urinary tract infection, kidney, pyelonephritis, sex differences

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology

Research summary
I am interested in studying the cellular and molecular mechanisms by which gut mycobiota (fungi) modulates local and systemic health with a goal to develop better biomarkers and therapeutic approaches.

Key words
microbiota, epithelium, arthritis, IBD

Program affiliation
Biochemistry Biophysics and Structural Biology
Cancer Biology
Molecular Cell Biology
Molecular Microbiology and Microbial Pathogenesis

Research summary
The rational structure-based drug design and synthesis for cancer and infectious disease

Key words
protease, kinase, cancer, infection, lectin, chemistry, synthesis, drug discovery, peptidomimetic, inhibitor