Molecular Microbiology and Microbial Pathogenesis
Jeffrey Haspel, MD, PhD
Associate Professor
- Email: jhaspel@wustl.edu
Program affiliation
Molecular Cell Biology
Molecular Microbiology and Microbial Pathogenesis
Biochemistry Biophysics and Structural Biology
Research summary
Understand the impact of time as a biological variable in the development of critical illness such as sepsis, respiratory failure and chronic inflammatory lung disease
Key words
Jeffrey Henderson, MD, PhD
Professor
- Email: hendersonj@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Microbiology and Microbial Pathogenesis
Research summary
Biochemical interactions between humans and bacteria in health and disease
Key words
bacterial pathogenesis, host-pathogen interactions, iron, mass spectrometry, medicinal chemistry, metabolomics
Michael Holtzman, MD
Selma and Herman Seldin Professor
- Email: mjholtzman@wustl.edu
Program affiliation
Immunology
Molecular Microbiology and Microbial Pathogenesis
Molecular Cell Biology
Research summary
New drugs for post-viral and related types of disease
Key words
drug discovery, innate immunity, epithelial stem cells, viruses, respiratory airway disease
Scott Hultgren, PhD
Helen L. Stoever Professor
- Email: hultgren@wustl.edu
Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Plant and Microbial Biosciences
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Research summary
Interdisciplinary approach combining genetics, genomics, biochemistry, structural biology, high-resolution imaging, animal models, clinical studies and combinatorial chemistry to determine key aspects of bacterial pathogenesis and apply our knowledge to development of new therapeutics.
Key words
antibiotic-sparing therapeutics, host-pathogen interactions, bacterial pathogenesis, drug and vaccine development, multi-drug resistant E. coli, MRSA, Enterococcus, Acinetobacter, Klebsiella, urinary tract infections (UTI)
David Hunstad, MD
Arnold W. Strauss, MD, Endowed Professor
- Email: dhunstad@wustl.edu
Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Research summary
Sex differences, virulence factors, and novel therapeutics in E. coli urinary tract infections
Key words
bacterial pathogenesis, Escherichia coli, host-pathogen interactions, innate immunity, novel therapeutics, urinary tract infection, kidney, pyelonephritis, sex differences
Umang Jain, PhD
Assistant Professor
- Email: ujain@wustl.edu
Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology
Research summary
I am interested in studying the cellular and molecular mechanisms by which gut mycobiota (fungi) modulates local and systemic health with a goal to develop better biomarkers and therapeutic approaches.
Key words
James Janetka, PhD
Professor
- Email: janetkaj@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Cancer Biology
Molecular Cell Biology
Molecular Microbiology and Microbial Pathogenesis
Research summary
The rational structure-based drug design and synthesis for cancer and infectious disease
Key words
protease, kinase, cancer, infection, lectin, chemistry, synthesis, drug discovery, peptidomimetic, inhibitor
Andrew Janowski, MD
Assistant Professor
- Email: abjanowski@wustl.edu
Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Neurosciences
Research summary
Characterization of human diseases associated with novel viral infections
Key words
Virology, microbiology, pathogen discovery, host-virus interactions, viral immunity, astroviruses, encephalitis, myocarditis, viral RNA structures
Andrew Kau, MD, PhD
Associate Professor
- Email: akau@wustl.edu
Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Immunology
Molecular Genetics and Genomics
Computational and Systems Biology
Research summary
Microbial community-immune interactions in airway diseases and urogenital tract
Key words
microbiota; microbiome; mucosal immunity; asthma; allergy; atopy; urinary tract infection; pathogen colonization; metabolomics;