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Jeffrey Haspel, MD, PhD

Associate Professor

Program affiliation
Molecular Cell Biology
Molecular Microbiology and Microbial Pathogenesis
Biochemistry Biophysics and Structural Biology

Research summary
Understand the impact of time as a biological variable in the development of critical illness such as sepsis, respiratory failure and chronic inflammatory lung disease

Key words

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Jeffrey Henderson, MD, PhD

Professor

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Microbiology and Microbial Pathogenesis

Research summary
Biochemical interactions between humans and bacteria in health and disease

Key words
bacterial pathogenesis, host-pathogen interactions, iron, mass spectrometry, medicinal chemistry, metabolomics

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Michael Holtzman, MD

Selma and Herman Seldin Professor

Program affiliation
Immunology
Molecular Microbiology and Microbial Pathogenesis
Molecular Cell Biology

Research summary
New drugs for post-viral and related types of disease

Key words
drug discovery, innate immunity, epithelial stem cells, viruses, respiratory airway disease

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Scott Hultgren, PhD

Helen L. Stoever Professor

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Plant and Microbial Biosciences
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology

Research summary
Interdisciplinary approach combining genetics, genomics, biochemistry, structural biology, high-resolution imaging, animal models, clinical studies and combinatorial chemistry to determine key aspects of bacterial pathogenesis and apply our knowledge to development of new therapeutics.

Key words
antibiotic-sparing therapeutics, host-pathogen interactions, bacterial pathogenesis, drug and vaccine development, multi-drug resistant E. coli, MRSA, Enterococcus, Acinetobacter, Klebsiella, urinary tract infections (UTI)

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David Hunstad, MD

Arnold W. Strauss, MD, Endowed Professor

Program affiliation
Molecular Microbiology and Microbial Pathogenesis

Research summary
Sex differences, virulence factors, and novel therapeutics in E. coli urinary tract infections

Key words
bacterial pathogenesis, Escherichia coli, host-pathogen interactions, innate immunity, novel therapeutics, urinary tract infection, kidney, pyelonephritis, sex differences

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Umang Jain, PhD

Assistant Professor

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology

Research summary
I am interested in studying the cellular and molecular mechanisms by which gut mycobiota (fungi) modulates local and systemic health with a goal to develop better biomarkers and therapeutic approaches.

Key words

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James Janetka, PhD

Professor

Program affiliation
Biochemistry Biophysics and Structural Biology
Cancer Biology
Molecular Cell Biology
Molecular Microbiology and Microbial Pathogenesis

Research summary
The rational structure-based drug design and synthesis for cancer and infectious disease

Key words
protease, kinase, cancer, infection, lectin, chemistry, synthesis, drug discovery, peptidomimetic, inhibitor

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Andrew Janowski, MD

Assistant Professor

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Neurosciences

Research summary
Characterization of human diseases associated with novel viral infections

Key words
Virology, microbiology, pathogen discovery, host-virus interactions, viral immunity, astroviruses, encephalitis, myocarditis, viral RNA structures

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Usheer Kanjee, PhD

Assistant Professor

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Biochemistry Biophysics and Structural Biology
Immunology
Molecular Genetics and Genomics

Research summary

Key words

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Andrew Kau, MD, PhD

Associate Professor

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Immunology
Molecular Genetics and Genomics
Computational and Systems Biology

Research summary
Microbial community-immune interactions in airway diseases and urogenital tract

Key words
microbiota; microbiome; mucosal immunity; asthma; allergy; atopy; urinary tract infection; pathogen colonization; metabolomics;