Neurosciences
David M. Holtzman, MD
Barbara Burton and Reuben M. Morriss III Distinguished Professor
- Email: holtzman@wustl.edu
Program affiliation
Neurosciences
Molecular Cell Biology
Research summary
Cellular and Molecular studies of Alzheimer’s disease
Key words
amyloid, tau, antibodies, apolipoprotein E, Alzheimer’s disease, neurodegeneration, neurobiology
Timothy E. Holy, PhD
Alan A. and Edith L. Wolff Professor
- Email: holy@wustl.edu
Program affiliation
Neurosciences
Computational and Systems Biology
Research summary
Sensory processing and plasticity (olfaction), large-population calcium imaging, computation, social communication
Key words
calcium imaging, physiology, mathematical modeling, behavior, neurobiology, smell, olfaction, pheromones, neuroendocrine, circuits
Cheng Huang, PhD
Assistant Professor
- Email: huang.cheng@wustl.edu
Program affiliation
Neurosciences
Molecular Cell Biology
Computational and Systems Biology
Research summary
Our lab deciphers how fruit flies learn, memorize, and make decisions using state-of-the-art optical imaging techniques
Key words
Voltage imaging, computational modeling, learning system, memory processing, Drosophila melanogaster
Eric J. Huang, MD, PhD
Joseph M. Davie Distinguished Professor and Chair of the Department of Pathology and Immunology
- Email: erichuang@wustl.edu
Program affiliation
Immunology
Neurosciences
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics
Research summary
Key words
Shin-ichiro Imai, MD, PhD
Professor
- Email: imaishin@wustl.edu
Program affiliation
Developmental Regenerative and Stem Cell Biology
Neurosciences
Molecular Genetics and Genomics
Molecular Cell Biology
Research summary
Understanding the molecular mechanism of aging and longevity in mammals
Key words
aging, longevity, hypothalamus, metabolism, NAD biosynthesis, Sirt1, NAMPT, NAD World
Masatoshi Inoue, PhD
Assistant Professor
- Email: inoue.m@wustl.edu
Program affiliation
Neurosciences
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology
Research summary
Our research program integrates protein engineering and systems neuroscience to address previously inaccessible questions about brain function, particularly in the area of social behavior.
Key words
Social Behavior, Protein engineering, Optics, Neural dynamics, Genetically encoded optical tools
Sayaka Inoue, PhD
Assistant Professor
- Email: sayaka@wustl.edu
Program affiliation
Neurosciences
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Research summary
We aim to understand neural basis controlling behaviors in females across the lifespan
Key words
neurobiology, behavior, hormone, plasticity, maturation, aging, optogenetics, calcium imaging, and circuit tracing
Joseph Ippolito, MD, PhD
Associate Professor
- Email: ippolitoj@wustl.edu
Program affiliation
Cancer Biology
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Neurosciences
Research summary
Precision medicine through metabolism-based imaging and therapy: from laboratory to clinical translation
Key words
cancer, metabolism, imaging, sex differences, body composition
Meredith E. Jackrel, PhD
Associate Professor
- Email: mjackrel@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Neurosciences
Research summary
Protein folding and misfolding, and the engineering and application of protein disaggregases to reverse misfolding
Key words
protein folding and misfolding; intrinsically disordered proteins, phase separation, and neurodegenerative disease; protein chaperones; protein engineering; amyloid; yeast models of protein misfolding
Joanna Jankowsky, PhD
Professor
- Email: jankowsky@wustl.edu
Program affiliation
Neurosciences
Molecular Genetics and Genomics
Molecular Cell Biology
Research summary
Cellular and molecular pathogenesis of Alzheimer's disease
Key words
Alzheimer's disease, neurodegeneration, amyloid, tau, mouse models, risk factors, lysosome, gene therapy