Neurosciences

Program affiliation
Human and Statistical Genetics
Molecular Genetics and Genomics
Computational and Systems Biology
Neurosciences

Research summary
Genetic underpinnings of neurological/neurosurgical disorders

Key words
rare variants, Chiari I malformation, human genetics, neurosurgery, Deep Mutation Scanning, Mutagenesis, Limb-girdle muscular dystrophy

Program affiliation
Immunology
Molecular Genetics and Genomics
Developmental Regenerative and Stem Cell Biology
Neurosciences

Research summary
The Han lab investigates microglia and brain macrophage phenotypes in neurodevelopmental and neurodegenerative contexts through the lens of epigenomics and transcriptomics. 

Key words
microglia, neurodevelopment, epigenetics, transcriptomics, neurodegeneration

Program affiliation
Neurosciences

Research summary
Learning-related hippocampal network activation

Key words
Learning, memory, behavior, virtual reality, in vivo two-photon imaging, dopamine, modeling, systems neuroscience

Program affiliation
Neurosciences

Research summary
Dr. Haroutounian studies neuropathic pain with a focus on determining individual predictors of treatment response to analgesic pharmacotherapy.

Key words

Program affiliation
Neurosciences

Research summary
Cognitive neuroscience of aging

Key words
aging, Alzheimer’s disease, cognition, imaging, structure-function relations

Program affiliation
Neurosciences
Computational and Systems Biology
Molecular Cell Biology

Research summary
We take a "big data" approach to understanding the self-organization of neurons and networks in behaving animals.

Key words
Homeostatic plasticity, behavior, neurodegeneration, self-organization, emergence, learning, computational, computation, modeling

Program affiliation
Neurosciences

Research summary
Clinical neuroscience of diabetes and related diseases

Key words
neuroimaging, diabetes, hyperglycemia, hypoglycemia, Wolfram Syndrome, Parkinson disease, cognition, mood

Program affiliation
Neurosciences
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology
Biomedical Informatics and Data Science

Research summary
Molecular, cellular and circuit analysis of daily rhythms in health and disease

Key words
neurobiology, behavior, imaging, circadian rhythm, glia, brain cancer, potassium channels, neuropeptides, cortex, astrocytes, glioblastoma, cancer, developmental biology, computational modeling

Program affiliation
Neurosciences
Computational and Systems Biology
Biomedical Informatics and Data Science

Research summary
Understanding the learning mechanisms of the brain from theoretical and computational perspectives

Key words
Computational Neuroscience, NeuroAI, Synaptic Plasticity, Olfaction, Continual Learning, Deep Learning

Program affiliation
Neurosciences

Research summary
Innate immunity in the inner ear

Key words
inflammation, inner ear, cochlear injury, monocytes, macrophages, blood labyrinth barrier