Neurosciences

Program affiliation
Neurosciences
Molecular Cell Biology

Research summary
Mechanisms of neurodegeneration in Parkinson`s disease and related disorders

Key words
lipid metabolism, mouse models, neurodegeneration, pathogenesis, phospholipase A2, Parkinson disease

Program affiliation
Neurosciences

Research summary
The study of basal ganglia circuits and how their function changes in disease states such as obesity, addiction, and anxiety disorders

Key words

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Neurosciences

Research summary
Transcriptional and epigenetic regulation of neural development and its dysregulation to cause neurodevelopmental disorders

Key words
human pluripotent stem cell, autism, neuron, neurodevelopmental disorders, cerebral organoid, epigenetic regulation, transcriptional regulation, neurobiology, embryonic stem cell, neural stem cell, transcription, gene regulatory network, chromatin, embryo

Program affiliation
Neurosciences
Biomedical Informatics and Data Science

Research summary
My lab uses transcranial focused ultrasound to provide noninvasive therapies of disorders of brain function.

Key words
neuromodulation, neural engineering

Program affiliation
Neurosciences
Computational and Systems Biology
Biomedical Informatics and Data Science

Research summary
Cortical synaptic, neural, and circuit mechanisms underlying auditory (hearing) deficits in neurological and neurodevelopmental disorders, including noise-induced hearing loss, hyperacusis, and autism. We employ a multidisciplinary approach including, in vivo two-photon microscopy in awake mice, auditory behavioral assays, ex vivo brain-slice imaging and electrophysiology, chemogenetic and optogenetic circuit manipulation, inducible conditional knockout models, and pharmacological interventions.

Key words
Auditory Neuroscience, Autism, Cortical Neural and Circuit Mechanisms, Auditory Driven Behavior, Two-photon Microscopy, Optogenetics/Chemogenetics

Program affiliation
Neurosciences

Research summary
Understanding the mechanisms underlying neuronal trauma and neurodegeneration during and following acute brain injury

Key words
traumatic brain injury, Alzheimer's disease, Alzheimer disease, microsscopy, imaging, microdialysis, MRI, diffusion tensor imaging

Program affiliation
Biomedical Informatics and Data Science
Neurosciences
Computational and Systems Biology

Research summary

Key words

Program affiliation
Neurosciences

Research summary
Understanding how sleep modulates stroke recovery and to discover new sleep-focused treatments

Key words
stroke, sleep torpor, plasticity, neuroprotection

Program affiliation
Neurosciences

Research summary
Movement control to advance rehabilitation outcomes

Key words
Motor control, motor learning, rehabilitation, wearable sensing

Program affiliation
Neurosciences
Computational and Systems Biology

Research summary

Key words