Neurosciences

Program affiliation
Biomedical Informatics and Data Science
Neurosciences

Research summary
The Lee Laboratory develops computational approaches to advance precision medicine through retinal imaging, artificial intelligence, and multimodal biomedical data. Our research integrates ophthalmic imaging, clinical phenotypes, wearable sensors, electronic health records, and multi-omics to discover noninvasive biomarkers of systemic diseases, including diabetes, Alzheimer's disease, and cardiovascular disease. Through large-scale collaborative studies such as Eye ACT, AI-READI, and the Framingham Heart Study Eye Project, we build open, AI-ready resources that accelerate scientific discovery and improve patient care.

Key words
Big Data, AI, Ophthalmology, Clinical Epidemiology, Alzheimer's, Oculomics

Program affiliation
Neurosciences
Computational and Systems Biology

Research summary
Pathogenesis of amyloid fibrils and amyloid plaques in AD mouse models

Key words
brain ischemia, stroke recovery, Alzheimer’s disease, amyloid

Program affiliation
Neurosciences

Research summary

Key words

Program affiliation
Neurosciences
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics

Research summary
Microglial biology and neuro-immune interactions in development, aging and disease

Key words
microglia, neuroimmunology, development, aging, neurodegeneration, single cell

Program affiliation
Biochemistry Biophysics and Structural Biology
Developmental Regenerative and Stem Cell Biology
Neurosciences

Research summary
The Li laboratory is dedicated to developing biomaterial platforms for regenerative medicine, specifically focusing on applications in angiogenesis, vascularization, stem cell engineering, and tissue regeneration.

Key words
Biomaterials, Tissue Engineering, Regenerative Medicine

Program affiliation
Computational and Systems Biology
Biomedical Informatics and Data Science
Molecular Genetics and Genomics
Cancer Biology
Neurosciences

Research summary
Our research interests include developing innovative computational tools/methods and utilizing single-cell (epi)genomic techniques to gain a comprehensive understanding of gene regulation in mammalian models and human diseases, particularly in brain tumors and neuropsychiatric disorders.

Key words
Bioinformatics, Gene Regulation, Single-cell Epigenetics, Brain Tumors, Neurological Disorders

Program affiliation
Biochemistry Biophysics and Structural Biology
Neurosciences

Research summary
Structure-function studies of Slo family K+ channels

Key words
ion channel, protein structure, neurobiology, physiology, cell signaling

Program affiliation
Neurosciences
Molecular Cell Biology

Research summary
The biology of itch

Key words
somatosensation, itch, primary sensory neurons, G protein-coupled receptors

Program affiliation
Neurosciences

Research summary
Genetic and molecular basis of ALS

Key words

Program affiliation
Neurosciences
Biochemistry Biophysics and Structural Biology

Research summary
Research in the laboratory is aimed at attaining functional selectivity of opioid agonist action from its own target adverse effects while integrating chemical synthesis with biochemical, genetic and pharmacological approaches.

Key words
opioids, GPCRs, biased signaling, pain, chemical biology