Neurosciences

Program affiliation
Computational and Systems Biology
Biomedical Informatics and Data Science
Molecular Genetics and Genomics
Cancer Biology
Neurosciences

Research summary
Our research interests include developing innovative computational tools/methods and utilizing single-cell (epi)genomic techniques to gain a comprehensive understanding of gene regulation in mammalian models and human diseases, particularly in brain tumors and neuropsychiatric disorders.

Key words
Bioinformatics, Gene Regulation, Single-cell Epigenetics, Brain Tumors, Neurological Disorders

Program affiliation
Neurosciences

Research summary
We study disorders of cerebrospinal fluid (CSF) physiology such as hydrocephalus and Chiari-associated syringomyelia

Key words
Pediatric neurosurgery, epilepsy surgery, neuro-endoscopy, hydrocephalus, pediatric brain tumors, deep brain stimulation, radiosurgery, pediatric spine

Program affiliation
Biochemistry Biophysics and Structural Biology
Neurosciences

Research summary
Structure-function studies of Slo family K+ channels

Key words
ion channel, protein structure, neurobiology, physiology, cell signaling

Program affiliation
Neurosciences
Molecular Cell Biology

Research summary
The biology of itch

Key words
somatosensation, itch, primary sensory neurons, G protein-coupled receptors

Program affiliation
Neurosciences

Research summary
The Lucey Lab undertakes both longitudinal studies of sleep, aging, and AD as well as clinical trial using sleep interventions to target AD pathology

Key words
Sleep, circadian rhythms, aging, Alzheimer's disease

Program affiliation
Neurosciences
Developmental Regenerative and Stem Cell Biology

Research summary
Investigation of peripheral nerve injury and regeneration

Key words
nerve regeneration, neuropathy, neurotrophins, peripheral nervous system, nerve allotransplantation, tissue engineering

Program affiliation
Neurosciences
Biochemistry Biophysics and Structural Biology

Research summary
Research in the laboratory is aimed at attaining functional selectivity of opioid agonist action from its own target adverse effects while integrating chemical synthesis with biochemical, genetic and pharmacological approaches.

Key words
opioids, GPCRs, biased signaling, pain, chemical biology

Program affiliation
Biomedical Informatics and Data Science
Neurosciences
Cancer Biology

Research summary
Artificial intelligence and informatics to support open science and translational research

Key words
informatics imaging AI open science

Program affiliation
Neurosciences
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
Understanding the neural mechanisms underlying emotional dysregulation in the contexts of stress, chronic pain, and addiction

Key words

Program affiliation
Neurosciences

Research summary
The use of mathematical techniques to improve our understanding of the development of Alzheimer`s Disease

Key words