Neurosciences

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Immunology
Neurosciences

Research summary
My research program integrates cardiovascular physiology, stem cell biology, developmental biology, functional genomics, and cardio-oncology to investigate molecular mechanisms of congenital and acquired cardiovascular diseases. My laboratory specializes in developing innovative protocols for generating authentic cardiovascular cell types from human induced pluripotent stem cells (iPSCs), advancing cardiovascular precision medicine. We aim to bridge basic science and clinical translation through disease modeling, therapeutic target identification, and adverse outcome prevention.

Key words
iPSC, CRISPR, organoid, cardiovascular, precision medicine, cardio-oncology

Program affiliation
Neurosciences

Research summary
Translational Brain MRI Clinical Applications; Neurophysiology Modeling Using MRI Methods

Key words
brain, imaging, magnetic resonance imaging, fMRI, DTI, perfusion, mathematical modeling

Program affiliation
Computational and Systems Biology
Cancer Biology
Biomedical Informatics and Data Science
Neurosciences

Research summary
I have multidisciplinary research interests spanning disease biology, engineering, imaging sciences, and informatics. Our work integrates computational imaging, artificial intelligence, and clinical/translational medicine to discover and validate quantitative imaging biomarkers and to define therapeutic endpoints in cancer and other diseases.

Key words
Computational medicine, cancer, systems biology and quantitative imaging

Program affiliation
Molecular Genetics and Genomics
Developmental Regenerative and Stem Cell Biology
Neurosciences

Research summary
Genetic analysis of neural and muscular development in the Drosophila embryo

Key words
development, neurobiology, cell signaling

Program affiliation
Neurosciences

Research summary
Investigating the effects of prematurity and other modifiable clinical and environmental risk factors on neurodevelopmental outcomes in high-risk pediatric populations

Key words
Neurodevelopment; neonate; prematurity; psychopathology; brain injury; MRI; structural connectivity; functional connectivity

Program affiliation
Neurosciences

Research summary
Information processing in the cerebral cortex

Key words
behavior, cognition, computational biology, eye-hand coordination, neurophysiology, systems neuroscience

Program affiliation
Neurosciences

Research summary
Imaging CNS function and pathology

Key words
diffusion, imaging, multiple sclerosis, retinal degeneration, spinal cord, White matter injury

Program affiliation
Neurosciences

Research summary
To understand and develop treatments for cerebrospinal fluid circulation disorders during development, including neonatal post-hemorrhagic hydrocephalus

Key words

Program affiliation
Neurosciences

Research summary
Characterizing functional brain network development in children with and without anxiety disorders, with the long-term goal of using this information to devise novel, mechanism-based treatments for pediatric anxiety disorders.

Key words

Program affiliation
Cancer Biology
Molecular Genetics and Genomics
Immunology
Molecular Cell Biology
Neurosciences

Research summary
Cancer-Stroma interactions in metastasis

Key words
cancer metastasis; tumor microenvironment, cancer immunology, CRISPR screen, quantitative biology