Neurosciences

Program affiliation
Neurosciences
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology
Molecular Genetics and Genomics
Computational and Systems Biology

Research summary
Understanding neuromodulator actions, sleep regulation and sleep, and mechanisms of learning through the spatial and temporal features of biochemical signaling dynamics

Key words
neuromodulator, sleep, dynamics, sensors, actuators, signaling, G protein coupled receptors, imaging, microscopy, learning, plasticity, engineering

Program affiliation
Neurosciences
Biochemistry Biophysics and Structural Biology

Research summary
The interface between systems and control engineering, neuroscience and neural medicine

Key words
Control of neural dynamics; Biophysical modeling of multiscale brain networks;

Program affiliation
Neurosciences

Research summary
Relationship between synaptic activtity and amyloid-beta metabolism in Alzheimer`s disease

Key words
Alzheimer’s disease, drug and target discovery, endocytosis, in vivo microdialysis, synaptic transmission

Program affiliation
Developmental Regenerative and Stem Cell Biology
Neurosciences
Molecular Genetics and Genomics

Research summary
Genetic and epigenetic control of retinal development and retinal cell fate specification

Key words

Program affiliation
Neurosciences
Molecular Genetics and Genomics
Developmental Regenerative and Stem Cell Biology
Computational and Systems Biology

Research summary
Disease mechanisms and treatments for inherited childhood neurodegeneration

Key words
Batten Disease, Neuronal Ceroid Lipofuscinosis, NCL, Lysosomal Storage Disease, pathogenesis, pre-clinical therapies, enzyme replacement, gene therapy

Program affiliation
Neurosciences
Developmental Regenerative and Stem Cell Biology
Biochemistry Biophysics and Structural Biology
Molecular Genetics and Genomics

Research summary
We study how different types of neurons encoding somatosensory modalities are assembled into functional circuits in both humans and model organisms.

Key words
pain, circuits, development, optogenetics, imaging, electrophysiology, human

Program affiliation
Molecular Genetics and Genomics
Neurosciences
Developmental Regenerative and Stem Cell Biology
Computational and Systems Biology

Research summary
(1) transcriptional networks in the retina; (2) the mechanistic basis of color vision; (3) the cis-regulatory basis of human uniqueness and neuropsychiatric disease

Key words
neurobiology, genomics, transcriptional networks, systems biology, photoreceptors, brain, neuropsychiatric disease, disease, cis-regulation

Program affiliation
Neurosciences

Research summary
Leveraging synaptic physiology to treat addiction and affective symptoms of pain

Key words
electrophysiology, deep brain stimulation, dopamine, basal ganglia, reward and aversion, addiction, genetics, pharmacology, optogenetics, pain

Program affiliation
Human and Statistical Genetics
Neurosciences
Biomedical Informatics and Data Science
Molecular Genetics and Genomics
Computational and Systems Biology

Research summary
The goal of my lab is to understand the biology of neurodegeneration by using high-dimensional omic data and functional genomic approaches.

Key words
Neurodegeneration, Alzheimer, genetics, genomics, proteomics, system biology, molecular phenotyping, functional genomics

Program affiliation
Neurosciences

Research summary
Non-invasive optical measurements for both functional- and molecular- biological imaging

Key words