Neurosciences

Program affiliation
Neurosciences

Research summary
Understanding how the primate brain processes sensory information to perceive the world as an organized collection of objects

Key words
primate, macaque, visual, auditory, cortex, electrophysiology, multiphoton imaging, optogenetics, perception, figure-ground, foreground, background, image segmentation, laminar circuit, cortical column, neuropixels, binocular disparity, depth, 3D

Program affiliation
Biochemistry Biophysics and Structural Biology
Cancer Biology
Neurosciences
Immunology
Developmental Regenerative and Stem Cell Biology

Research summary
Small molecule drug discovery inspired research across multiple therapeutic areas including chronic pain, oncology, and neurodegeneration.

Key words
drug discovery, medicinal chemistry, chemical biology, synthetic methods

Program affiliation
Biochemistry Biophysics and Structural Biology
Neurosciences
Immunology
Plant and Microbial Biosciences
Molecular Microbiology and Microbial Pathogenesis

Research summary
Dr. Fu’s research focuses on the structural and functional analysis of SPFH family proteins. Using cryo-electron microscopy and cryo-electron tomography, the Fu Lab studies membrane proteins in their native environments to explore their role in cellular signaling and disease

Key words
cryoem structure Ion channel membrane protein cryoet

Program affiliation
Neurosciences
Molecular Genetics and Genomics
Molecular Cell Biology

Research summary
Exploration of functions for neuron-specific regulators of gene expression, leveraging genes and mechanisms implicated in human neurologic disease to point us toward critical pathways in the brain.

Key words
Epigenetics, Neurodevelopment, Rett syndrome, non-CpG DNA methylation, Transcription, Autism Spectrum Disorder, Neurodevelopmental disease

Program affiliation
Neurosciences
Molecular Cell Biology

Research summary
Understand the molecular mechanisms that regulate reactive astrocytes and their neurotoxicity in
neurodegenerative diseases, including Alzheimer’s disease, by utilizing a combination of biochemistry, molecular biology, cellular models of inflammation and mouse models of neurodegenerative diseases.

Key words

Program affiliation
Neurosciences

Research summary
Elucidating and understanding molecular mechanisms of axonal degeneration and regeneration in neuropathies

Key words

Program affiliation
Neurosciences
Molecular Cell Biology

Research summary
Cellular and molecular mechanisms of chronic pain, preclinical and translational research

Key words
pain, optogenetics, ion channel, synaptic transmission, signal transduction, electrophysiology, in vivo imaging, genetics

Program affiliation
Neurosciences
Biomedical Informatics and Data Science

Research summary
Our laboratory develops and uses novel neuroanatomical and neuroimaging computerized brain mapping methods to study the structure, function, connectivity, parcellation, development, and evolution of cerebral cortex in humans and nonhuman primates in health and disease.

Key words
Neuroanatomy Connectomics Neuroimaging Neuroradiology Medical Image Analysis

Program affiliation
Molecular Cell Biology
Neurosciences

Research summary

Key words

Program affiliation
Neurosciences
Developmental Regenerative and Stem Cell Biology
Computational and Systems Biology

Research summary
Understanding the computational principles that underly brain development, using a combination of experimental and theoretical approaches

Key words