Programs

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Molecular Genetics and Genomics
Immunology
Developmental Regenerative and Stem Cell Biology

Research summary
To address the central mandate of gene therapy we engineer adenovirus tropism to allow the achievement of effective gene delivery

Key words
Adenovirus, virotherapy, virus, cancer, gene therapy, vaccine

Program affiliation
Biochemistry Biophysics and Structural Biology
Neurosciences
Molecular Microbiology and Microbial Pathogenesis
Molecular Cell Biology

Research summary
My lab aims to establish the fundamental principles of intracellular physical chemistry and electrochemical functions of macromolecular complexes, and design synthetic proteins as therapeutics for condensate-dependent diseases.

Key words
molecular biology; physical chemistry; biochemistry; biophysics; synthetic biology; electrochemistry; phase transition; condensates

Program affiliation
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics

Research summary
My research aims to understand the lung vascular homeostasis and the pathogenesis of pulmonary diseases using novel animal models, integrated pharmacological approaches, genome editing and single cell RNA-sequencing and spatial transcriptomics.

Key words
cardiovascular, lung, vascular, single cell, spatial transcriptomic

Program affiliation
Neurosciences
Cancer Biology
Immunology

Research summary
The primary research goal of our laboratory is to uncover novel ways to alter the pediatric brain tumor microenvironment to enhance the efficacy of existing treatments and make treatments safer for children.

Key words
brain tumors, cancer, neurology, immunology, imaging

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Computational and Systems Biology
Molecular Genetics and Genomics
Biochemistry Biophysics and Structural Biology

Research summary
(1) Dynamics, ecology, and evolution of antibiotic resistance, (2) Engineering enhanced probiotics to treat GI disorders, (3) Engineering microbial biofuel catalysts

Key words
anibiotic resistance, synthetic biology, bioenergy, human microbiome, metagenomics, microbial ecology and biodiversity

Program affiliation
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology
Biomedical Informatics and Data Science

Research summary
Mammalian gene expression: Regulation through mRNA editing and RNA stabilization

Key words
gene expression, RNA, cancer, mRNA editing, mRNA stability

Program affiliation
Molecular Genetics and Genomics

Research summary
Noninvasive characterization of heart function in patients with high blood pressure

Key words
imaging, hypertrophy, myocardial bloodflow

Program affiliation
Neurosciences
Molecular Cell Biology
Immunology
Biochemistry Biophysics and Structural Biology

Research summary
Understanding the molecular and cellular mechanisms of protein aggregation and neurodegeneration in Parkinson disease and dementia with Lewy bodies

Key words

Program affiliation
Biomedical Informatics and Data Science
Biochemistry Biophysics and Structural Biology
Computational and Systems Biology
Plant and Microbial Biosciences

Research summary
We integrate metabolic, movement, and community ecology to address core and applied ecological and evolutionary questions. Spanning diverse species and habitats, our research links individual physiology to global biodiversity patterns using theory, data, experiments, and field studies. We aim to understand ecological systems, including human impacts, to inform effective management and policy.

Key words
metabolism, movement ecology, community ecology, behavior, species interactions, human-nature interactions, biogeography, global change, computer vision, eco-informatics, complex systems, biodiversity, great river systems, ecological management

Program affiliation
Cancer Biology
Molecular Cell Biology
Immunology

Research summary
Molecular Mechanisms of Immune Regulation of Tumor Progression.

Key words
immunotherapy, breast cancer, pancreatic cancer, immunology, inflammation, metastasis, storm