Programs

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Computational and Systems Biology
Molecular Cell Biology
Plant and Microbial Biosciences

Research summary
Role of the human gut microbiome in health and disease, notably childhood undernutrition and obesity

Key words
Gut microbiome; systems biology; postnatal development; childhood malnutrition; global health; gnotobiotic animal models; metabolic regulation; food webs; gut-brain axis; gut barrier/immune function; microbiome-targeted therapeutics

Program affiliation
Biomedical Informatics and Data Science

Research summary

Key words

Program affiliation
Neurosciences

Research summary
Integrated advanced imaging approach to studying human brain aging

Key words

Program affiliation
Biochemistry Biophysics and Structural Biology
Computational and Systems Biology

Research summary

Key words

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology

Research summary
Relationship of structure to function in allosteric control mechanisms

Key words
protein structure, protein function, allosteric regulation, enzymology, biochemistry

Program affiliation
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics

Research summary
The etiology of mutagenesis and genome instability in pediatric cancers

Key words
leukemia, pediatric cancer, DNA damage, DNA replication, hematopoiesis

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology

Research summary
My long-term research interest focuses on the generation and transduction of mechanical forces in cardiovascular disease. In particular, my lab utilizes an array of biophysical, biochemical, cell biological, and engineering techniques to decipher how mutations associated with familial cardiomyopathies drive disease pathogenesis at the molecular, cellular, and tissue levels. My lab is also working to develop precision medicine approaches for pediatric and adult heart failure.

Key words
single molecule, biophysics, heart disease, myosin, optical trapping, cardiac muscle, stem cells, tissue engineering, cytoskeletal molecular motors, mechanobiology, computational modeling, precision medicine

Program affiliation
Molecular Genetics and Genomics
Cancer Biology
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology

Research summary
Deciphering the molecular mechanisms of epigenetics and how when this goes awry diseases arise

Key words
Epigenetics, Transgenerational, Imprinting, Evolution, Multicellularity, Cancer, Tumorigenesis, Epitranscriptomics

Program affiliation
Molecular Genetics and Genomics
Biomedical Informatics and Data Science
Cancer Biology
Computational and Systems Biology

Research summary
Improving our understanding of human disease biology and the development of personalized medicine strategies using genomics and informatics technologies

Key words
genomics, bioinformatics, data mining, immunogenomics, precision medicine, personalized medicine, cancer vaccines, and cancer research

Program affiliation
Biomedical Informatics and Data Science
Cancer Biology
Molecular Cell Biology
Immunology

Research summary
Development of personalized medicine strategies for cancer using genomic technologies

Key words
bioinformatics, machine learning, cancer, genomics, immunogenomics, precision oncology