Programs

Program affiliation
Cancer Biology
Immunology
Molecular Cell Biology

Research summary
Advancing knowledge of the mechanisms responsible for colorectal tumor progression, with a specific focus on Stress and its influence on the Tumor Microenvironment.

Key words
Tumor Microenvironment, Stress

Program affiliation
Neurosciences

Research summary
Cognitive neuroscience of aging

Key words
aging, Alzheimer’s disease, cognition, imaging, structure-function relations

Program affiliation
Human and Statistical Genetics
Biomedical Informatics and Data Science

Research summary
Genetic studies of alcoholism, smoking and drug dependence, depression, suicidality and anxiety disorders, personality disorders, and methodological research in genetic epidemiology

Key words
substance abuse, development, modeling, psychiatry, quantitative genetics

Program affiliation
Biochemistry Biophysics and Structural Biology

Research summary
Utilization of nucleic acid molecular recognition and self-assembly to generate functional architectures for biosensing and bioimaging

Key words
Chemical Biology, Molecular Recognition, Biomolecular Assembly, Nucleic Acids, Biosensors, Cellular Imaging, RNA Editing, Biomaterials

Program affiliation
General

Research summary
My research centers on defining how the dynamic conformational landscape of drug targets governs ligand binding, selectivity, and downstream signaling. Using integrated approaches—including molecular dynamics simulations, pharmacophore modeling, and virtual screening—I identify and characterize novel modulators for several targts. These studies uncover previously unrecognized binding pockets, reveal mechanisms of ligand-induced activation or inhibition

Key words

Program affiliation
General

Research summary
Redox biochemistry in cell signaling and disease, Proteomics

Key words
proteomics, post-translational modification, cysteine, redox, mass spectrometry, oxidation

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Microbiology and Microbial Pathogenesis

Research summary
Biochemical interactions between humans and bacteria in health and disease

Key words
bacterial pathogenesis, host-pathogen interactions, iron, mass spectrometry, medicinal chemistry, metabolomics

Program affiliation
Neurosciences
Computational and Systems Biology
Molecular Cell Biology

Research summary
We take a "big data" approach to understanding the self-organization of neurons and networks in behaving animals.

Key words
Homeostatic plasticity, behavior, neurodegeneration, self-organization, emergence, learning, computational, computation, modeling

Program affiliation
Molecular Cell Biology

Research summary
We aim to identify cellular and molecular mechanisms in the novel and rapidly expanding field of interorgan crosstalk in health and disease.

Key words

Program affiliation
Neurosciences

Research summary
Clinical neuroscience of diabetes and related diseases

Key words
neuroimaging, diabetes, hyperglycemia, hypoglycemia, Wolfram Syndrome, Parkinson disease, cognition, mood