Programs

Program affiliation
General

Research summary
Gene regulation and biogenesis of extracellular components in bacteria

Key words
bacteria, gene expression, protein structure, plant biosensors, cytochromes

Program affiliation
Neurosciences

Research summary
The study of basal ganglia circuits and how their function changes in disease states such as obesity, addiction, and anxiety disorders

Key words

Program affiliation
Immunology
Molecular Cell Biology

Research summary

Key words

Program affiliation
General

Research summary
circadian system influence on the limbic system during Alzheimer's disease pathogenesis and aging

Key words
Alzheimer's Disease, Circadian System, Hippocampal Physiology, Neurodegeneration

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Neurosciences

Research summary
Transcriptional and epigenetic regulation of neural development and its dysregulation to cause neurodevelopmental disorders

Key words
human pluripotent stem cell, autism, neuron, neurodevelopmental disorders, cerebral organoid, epigenetic regulation, transcriptional regulation, neurobiology, embryonic stem cell, neural stem cell, transcription, gene regulatory network, chromatin, embryo

Program affiliation
Neurosciences
Biomedical Informatics and Data Science

Research summary
My lab uses transcranial focused ultrasound to provide noninvasive therapies of disorders of brain function.

Key words
neuromodulation, neural engineering

Program affiliation
Neurosciences
Computational and Systems Biology
Biomedical Informatics and Data Science

Research summary
Cortical synaptic, neural, and circuit mechanisms underlying auditory (hearing) deficits in neurological and neurodevelopmental disorders, including noise-induced hearing loss, hyperacusis, and autism. We employ a multidisciplinary approach including, in vivo two-photon microscopy in awake mice, auditory behavioral assays, ex vivo brain-slice imaging and electrophysiology, chemogenetic and optogenetic circuit manipulation, inducible conditional knockout models, and pharmacological interventions.

Key words
Auditory Neuroscience, Autism, Cortical Neural and Circuit Mechanisms, Auditory Driven Behavior, Two-photon Microscopy, Optogenetics/Chemogenetics

Program affiliation
Neurosciences

Research summary
Understanding the mechanisms underlying neuronal trauma and neurodegeneration during and following acute brain injury

Key words
traumatic brain injury, Alzheimer's disease, Alzheimer disease, microsscopy, imaging, microdialysis, MRI, diffusion tensor imaging

Program affiliation
Biomedical Informatics and Data Science
Neurosciences
Computational and Systems Biology

Research summary

Key words

Program affiliation
Plant and Microbial Biosciences
Molecular Microbiology and Microbial Pathogenesis
Molecular Genetics and Genomics

Research summary
Molecular genetic analysis of disease development in Pseudomonas syringae-Arabidopsis interactions

Key words
plant-microbe interactions, bacterial pathogenesis, auxin, IAA, Type III effector protein, genetics, plant biology