Programs

Program affiliation
Cancer Biology
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics
Molecular Cell Biology

Research summary
Causes and new approaches to curing high-risk pediatric leukemia

Key words
Cancer biology, stem cell, hematopoiesis, leukemia, developmental biology

Program affiliation
Cancer Biology
Immunology
Molecular Cell Biology
Molecular Genetics and Genomics

Research summary
My laboratory studies the pathogenic role of epigenetic regulators in prostate cancer development and progression, with a focus on the mechanisms by which these factors co-operate with transcription factors to drive tumor heterogeneity and resistance to various standard of care therapies

Key words
Epigenetics, prostate cancer, transcriptomics, small molecule therapeutics, radioresistance, DNA damage signaling, tumor-immune dynamics.

Program affiliation
Molecular Genetics and Genomics
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology
Cancer Biology

Research summary
How tyrosine phosphorylation regulates epigenetic processes that affect cellular homeostasis and cancer cell survival

Key words

Program affiliation
Cancer Biology
Computational and Systems Biology
Molecular Genetics and Genomics
Human and Statistical Genetics

Research summary
Translational Cancer Genomics; Noncoding RNAs

Key words
non-coding RNAs, lncRNAs, cancer genomics, transcriptome, bioinformatics, computational biology, solid tumor malignancies

Program affiliation
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
The microtubule cytoskeleton in health and disease

Key words
Cell cytoskeleton, microtubules, cilia, centrosome, cell cycle, signal transduction, kidney/lung development and disease

Program affiliation
Cancer Biology
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Computational and Systems Biology

Research summary
Studying how perturbation of specific signal transduction pathways contributes to the initiation, progression and dissemination of cancer

Key words
proteomics, functional genomics, lung cancer, signal transduction, WNT, oxidative stress

Program affiliation
Neurosciences
Biochemistry Biophysics and Structural Biology

Research summary
Research in the laboratory is aimed at attaining functional selectivity of opioid agonist action from its own target adverse effects while integrating chemical synthesis with biochemical, genetic and pharmacological approaches.

Key words
opioids, GPCRs, biased signaling, pain, chemical biology

Program affiliation
Plant and Microbial Biosciences
Molecular Microbiology and Microbial Pathogenesis

Research summary
How the environment shapes host-associated microbial communities both within and across species

Key words
Gut microbiome, nonhuman primates, environmental health

Program affiliation
Plant and Microbial Biosciences
Computational and Systems Biology
Biomedical Informatics and Data Science

Research summary
The Mansfeld Lab uses various non‑model species and a hypothesis driven, systems approach to examine how circadian rhythm, development, and tissue type impact plant defense.

Key words
Plant Pathology, Genomics, Bioinformatics, Disease Resistance

Program affiliation
Biomedical Informatics and Data Science
Neurosciences
Cancer Biology

Research summary
Artificial intelligence and informatics to support open science and translational research

Key words
informatics imaging AI open science