Programs

Program affiliation
Neurosciences

Research summary
Cerebral cortex in humans and nonhuman primates: structure, function, connectivity, development, and evolution

Key words
neurobiology, vision, cerebral cortex, brain mapping, connectomics

Program affiliation
Molecular Cell Biology
Molecular Microbiology and Microbial Pathogenesis
Immunology
Cancer Biology

Research summary
The bone microenvironment for cancer and infection

Key words
bone biology, osteoclast, cancer, metastasis, osteoporosis, microenvironment, osteoblast, osteomyelitis, infection

Program affiliation
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Biochemistry Biophysics and Structural Biology

Research summary
Understanding DNA repair mechanisms that impact cancer etiology and responses to chemotherapies

Key words
DNA repair and replication; Genomic instability in cancers; Oncogenes; BRCA-mutation

Program affiliation
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics

Research summary
DNA replication and repair, and the roles of these pathways on cancer initiation, progression and response to chemotherapy and immunotherapy

Key words
genome stability, DNA repair, DNA replication, chemotherapy response, cancer etiology

Program affiliation
Immunology
Neurosciences
Molecular Cell Biology

Research summary
The Walsh Lab is dedicated to defining the immunological landscape of the eye and how this process goes awry in uveitis. We utilize molecular and systems-level approaches to understand how local immune cells and systemic immunity collaborate to maintain ocular homeostasis or drive pathology, with a particular interest in the communication between the gut, eye, and brain.

Key words
Autoimmunity, CD4 T cell biology, Uveitis, CNS border immunology, Translational Research

Program affiliation
Molecular Genetics and Genomics
Cancer Biology

Research summary
Genetics and genomics of blood cancer: mutation discovery and mouse models

Key words
cancer, functional genomics, gene expression profiling, hematopoiesis, stem cells, tumor biology

Program affiliation
Immunology

Research summary
Pathogenesis and therapeutics in tissue-specific autoimmunity

Key words
Autoimmunity Neoantigens Tolerance Diabetes T cells Dendritic cells Macrophages

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Immunology
Computational and Systems Biology
Plant and Microbial Biosciences

Research summary
Discovery and Characterization of Novel Viruses

Key words
microbial pathogenesis, functional genomics, virology, genome analysis, computational biology

Program affiliation
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology
Cancer Biology
Neurosciences

Research summary
We study how the major microtubule organizing center of animal cells, the centrosome, is formed and regulated to enable cell division and signaling

Key words
Centrosomes, cilia, microtubules, cytoskeleton, organelles, subcellular organization, cell dynamics, mitosis, cell cycle, cell biology, biochemistry

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics
Molecular Cell Biology

Research summary
We use mouse genetics to study signaling networks that control eye development and homeostasis

Key words
lens, lacrimal gland, signaling, FGF, mTOR