Biochemistry Biophysics and Structural Biology

Program affiliation
Biochemistry Biophysics and Structural Biology
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Molecular Genetics and Genomics

Research summary
The cellular response to life threatening human diseases.

Key words
serpins, cell death, lysosomes, necrotizing enterocolitis, C. elegans, proteases, protein misfolding, alpha-1 antitrypsin deficiency, drug discovery

Program affiliation
Biochemistry Biophysics and Structural Biology

Research summary
Plasmonic biosensors and biomimetic sensors

Key words
biomimetic sensors, plasmonic biosensors, nanostructures, transduction platforms

Program affiliation
Immunology
Cancer Biology
Computational and Systems Biology
Biochemistry Biophysics and Structural Biology

Research summary
Understanding how synthetic antigen receptors direct T cell function and dysfunction in the treatment of blood cancers

Key words
CAR T cell therapy, immunotherapy for cancer, T cell signaling, T cell dysfunction, lineage decisions

Program affiliation
Biochemistry Biophysics and Structural Biology

Research summary
Role of disordered proteins in function and dysfunction: from Alzheimer's disease to SARS CoV 2

Key words
disordered proteins, single molecule, fluorescence, FRET, Alzheimer's disease, SARS CoV 2 nucleocapsid, Apolipoprotein E, ApoE, biomolecular condensates, polymer models

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Immunology
Plant and Microbial Biosciences
Biochemistry Biophysics and Structural Biology

Research summary
Molecular pathogenesis of Mycobacterium tuberculosis

Key words
bacteria, gene regulation, molecular genetics, microbiology, pathogenesis, transcription, infectious disease, innate immunity

Program affiliation
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Biochemistry Biophysics and Structural Biology

Research summary
Examining the role the tumor microenvironment plays in immune modulation, tumor development, metastasis and dormancy

Key words
aging, cancer, microenvironment, RNAi, senescence, telomere

Program affiliation
Computational and Systems Biology
Molecular Genetics and Genomics
Human and Statistical Genetics
Biochemistry Biophysics and Structural Biology

Research summary
Computational biology, bioinformatics, protein-DNA interactions, gene regulation

Key words
computational biology, genome analysis, gene expression, mathematical modeling

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Biochemistry Biophysics and Structural Biology

Research summary
The Stratman lab is broadly interested in how blood vessels form and stabilize during development, and how changes in these processes affect tissue homeostasis and disease.

Key words
mechanobiology, vascular, endothelial cell, blood flow

Program affiliation
Biochemistry Biophysics and Structural Biology
Computational and Systems Biology
Molecular Microbiology and Microbial Pathogenesis
Biomedical Informatics and Data Science
Molecular Genetics and Genomics

Research summary

Key words
protein design, protein engineering, influenza, RSV, machine learning , vaccines, antivirals

Program affiliation
Cancer Biology
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
Identify and define those molecular features that drive leukemogenesis and then use that information to develop rational therapeutic strategies for improving outcomes in acute leukemia

Key words
leukemia, metabolism, therapy resistance, stem cells