Biochemistry Biophysics and Structural Biology

Program affiliation
Biochemistry Biophysics and Structural Biology

Research summary
Role of disordered proteins in function and dysfunction: from Alzheimer's disease to SARS CoV 2

Key words
disordered proteins, single molecule, fluorescence, FRET, Alzheimer's disease, SARS CoV 2 nucleocapsid, Apolipoprotein E, ApoE, biomolecular condensates, polymer models

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Immunology
Plant and Microbial Biosciences
Biochemistry Biophysics and Structural Biology

Research summary
Molecular pathogenesis of Mycobacterium tuberculosis

Key words
bacteria, gene regulation, molecular genetics, microbiology, pathogenesis, transcription, infectious disease, innate immunity

Program affiliation
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Biochemistry Biophysics and Structural Biology

Research summary
Examining the role the tumor microenvironment plays in immune modulation, tumor development, metastasis and dormancy

Key words
aging, cancer, microenvironment, RNAi, senescence, telomere

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Biochemistry Biophysics and Structural Biology

Research summary
The Stratman lab is broadly interested in how blood vessels form and stabilize during development, and how changes in these processes affect tissue homeostasis and disease.

Key words
mechanobiology, vascular, endothelial cell, blood flow

Program affiliation
Biochemistry Biophysics and Structural Biology
Computational and Systems Biology
Molecular Microbiology and Microbial Pathogenesis
Biomedical Informatics and Data Science
Molecular Genetics and Genomics

Research summary

Key words
protein design, protein engineering, influenza, RSV, machine learning , vaccines, antivirals

Program affiliation
Cancer Biology
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
Identify and define those molecular features that drive leukemogenesis and then use that information to develop rational therapeutic strategies for improving outcomes in acute leukemia

Key words
leukemia, metabolism, therapy resistance, stem cells

Program affiliation
Biochemistry Biophysics and Structural Biology

Research summary
The biological regulation of skeletal matrix quality

Key words

Program affiliation
Computational and Systems Biology
Plant and Microbial Biosciences
Biochemistry Biophysics and Structural Biology
Molecular Microbiology and Microbial Pathogenesis

Research summary
Metabolism analysis and metabolic engineering of environmental microorganisms for biofuel/chemical production

Key words
Metabolic flux analysis, bioenergy, metabolic engineering, algal bioprocess, bioremediation, kinetic modeling

Program affiliation
Neurosciences
Computational and Systems Biology
Biochemistry Biophysics and Structural Biology
Biomedical Informatics and Data Science

Research summary
Applying concepts and methods from statistical physics and mathematics to the study of the brain

Key words
theoretical and computational neuroscience, statistical physics

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology

Research summary
Structure-activity relationships in UV mutagenesis; nucleic acid-based chemotherapeutic and imaging agents

Key words
cancer, drug delivery, imaging, mutagenesis, nanotechnology, telomere