Biochemistry Biophysics and Structural Biology

Program affiliation
Molecular Cell Biology
Molecular Genetics and Genomics
Molecular Microbiology and Microbial Pathogenesis
Biochemistry Biophysics and Structural Biology

Research summary
Epigenetic regulation of phenotypes by propagation of prions in yeast

Key words
amyloid, chaperones, epigenetics, neurodegeneration, prion, yeast

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Biochemistry Biophysics and Structural Biology

Research summary
Biophysical mechanisms of infectious disease

Key words

Program affiliation
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Biochemistry Biophysics and Structural Biology

Research summary
Understanding DNA repair mechanisms that impact cancer etiology and responses to chemotherapies

Key words
DNA repair and replication; Genomic instability in cancers; Oncogenes; BRCA-mutation

Program affiliation
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
Cardiovascular mechanics, how the heart and blood vessels respond to mechanical forces

Key words
biomechanics, artery, elastin, matrix

Program affiliation
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology
Cancer Biology
Neurosciences

Research summary
We study how the major microtubule organizing center of animal cells, the centrosome, is formed and regulated to enable cell division and signaling

Key words
Centrosomes, cilia, microtubules, cytoskeleton, organelles, subcellular organization, cell dynamics, mitosis, cell cycle, cell biology, biochemistry

Program affiliation
Biochemistry Biophysics and Structural Biology
Plant and Microbial Biosciences
Molecular Microbiology and Microbial Pathogenesis

Research summary
Antibiotic drug discovery

Key words

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Biochemistry Biophysics and Structural Biology
Immunology
Molecular Cell Biology

Research summary
The Whelan laboratory studies the biology of negative-strand (NS) RNA viruses, divided between two major areas of focus: viral gene expression and viral-host cell interactions.

Key words

Program affiliation
Molecular Genetics and Genomics
Computational and Systems Biology
Molecular Cell Biology
Biomedical Informatics and Data Science
Biochemistry Biophysics and Structural Biology

Research summary
My lab seeks to understand how DNA sequence determines its regulatory function. We combine functional genomic technologies with deep learning models to answer this question.

Key words
computational biology, gene regulation, genomics, deep learning, technology development

Program affiliation
Developmental Regenerative and Stem Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
Role of transcription factors in differentiation and development

Key words
embryonic development, lung development, mouse models, transcriptional regulation

Program affiliation
Biochemistry Biophysics and Structural Biology
Neurosciences
Molecular Cell Biology
Cancer Biology

Research summary
Alzheimer’s disease, Parkinson's disease, central nervous disorders, postmortem biomarker validation and characterization, in vivo positron emission tomography, in vitro quantitative autoradiography

Key words
Imaging, biomarkers, cancer, neuroscience, PET, quantitative autoradiography, pharmaceuticals, biological assays, human brain function and disease