Computational and Systems Biology

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Computational and Systems Biology
Molecular Cell Biology
Plant and Microbial Biosciences

Research summary
Role of the human gut microbiome in health and disease, notably childhood undernutrition and obesity

Key words
Gut microbiome; systems biology; postnatal development; childhood malnutrition; global health; gnotobiotic animal models; metabolic regulation; food webs; gut-brain axis; gut barrier/immune function; microbiome-targeted therapeutics

Program affiliation
Molecular Genetics and Genomics
Biomedical Informatics and Data Science
Cancer Biology
Computational and Systems Biology

Research summary
Improving our understanding of human disease biology and the development of personalized medicine strategies using genomics and informatics technologies

Key words
genomics, bioinformatics, data mining, immunogenomics, precision medicine, personalized medicine, cancer vaccines, and cancer research

Program affiliation
Biomedical Informatics and Data Science
Human and Statistical Genetics
Computational and Systems Biology

Research summary
Statistical genetics and bioinformatics, high-dimensional data analysis and complex systems modeling, developing novel methodologies for detecting complex disease genes and characterizing their function

Key words
genetic epidemiology, statistical genetics

Program affiliation
Human and Statistical Genetics
Molecular Genetics and Genomics
Computational and Systems Biology
Neurosciences

Research summary
Genetic underpinnings of neurological/neurosurgical disorders

Key words
rare variants, Chiari I malformation, human genetics, neurosurgery, Deep Mutation Scanning, Mutagenesis, Limb-girdle muscular dystrophy

Program affiliation
Computational and Systems Biology
Molecular Microbiology and Microbial Pathogenesis
Immunology

Research summary

Key words

Program affiliation
Immunology
Computational and Systems Biology

Research summary
Studying effects of dysregulated nutrients in the tumor microenvironment on anti-tumor immunity.

Key words
immunometabolism, tumor immunology, polyamine transport

Program affiliation
Neurosciences
Computational and Systems Biology
Molecular Cell Biology

Research summary
We take a "big data" approach to understanding the self-organization of neurons and networks in behaving animals.

Key words
Homeostatic plasticity, behavior, neurodegeneration, self-organization, emergence, learning, computational, computation, modeling

Program affiliation
Neurosciences
Computational and Systems Biology
Biomedical Informatics and Data Science

Research summary
Understanding the learning mechanisms of the brain from theoretical and computational perspectives

Key words
Computational neuroscience, Synaptic plasticity, Olfaction, Deep learning

Program affiliation
Biochemistry Biophysics and Structural Biology
Computational and Systems Biology
Molecular Cell Biology
Plant and Microbial Biosciences

Research summary
Understand how function is encoded into disordered sequences using a combination of computational and experimental approaches

Key words

Program affiliation
Neurosciences
Computational and Systems Biology

Research summary
Sensory processing and plasticity (olfaction), large-population calcium imaging, computation, social communication

Key words
calcium imaging, physiology, mathematical modeling, behavior, neurobiology, smell, olfaction, pheromones, neuroendocrine, circuits