Computational and Systems Biology

Program affiliation
Biomedical Informatics and Data Science
Computational and Systems Biology
Cancer Biology

Research summary
Integrative large-scale pharmaco genomics analysis for target, signaling network, drug and drug combination discovery. Genomics data driven tumor-stromal communication discovery and modeling.

Key words

Program affiliation
Computational and Systems Biology
Biochemistry Biophysics and Structural Biology
Biomedical Informatics and Data Science

Research summary
Control and optimization of large-scale complex systems with applications ranging from quantum mechanics and neuroscience to bioinformatics

Key words
computational mathematics, control theory, optimization, dynamical systems, MRI, NMR, neuroscience

Program affiliation
Computational and Systems Biology
Biomedical Informatics and Data Science
Molecular Genetics and Genomics
Cancer Biology
Neurosciences

Research summary
Our research interests include developing innovative computational tools/methods and utilizing single-cell (epi)genomic techniques to gain a comprehensive understanding of gene regulation in mammalian models and human diseases, particularly in brain tumors and neuropsychiatric disorders.

Key words
Bioinformatics, Gene Regulation, Single-cell Epigenetics, Brain Tumors, Neurological Disorders

Program affiliation
Computational and Systems Biology
Ecology and Evolutionary Biology
Molecular Microbiology and Microbial Pathogenesis
Plant and Microbial Biosciences

Research summary
A computational and experimental lab studying bacterial colonization and transmission at the boundary of built and natural environments and exploring microbiomes as environmental sensors and public health sentinels

Key words

Program affiliation
Cancer Biology
Computational and Systems Biology
Molecular Genetics and Genomics
Human and Statistical Genetics

Research summary
Translational Cancer Genomics; Noncoding RNAs

Key words
non-coding RNAs, lncRNAs, cancer genomics, transcriptome, bioinformatics, computational biology, solid tumor malignancies

Program affiliation
Cancer Biology
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Computational and Systems Biology

Research summary
Studying how perturbation of specific signal transduction pathways contributes to the initiation, progression and dissemination of cancer

Key words
proteomics, functional genomics, lung cancer, signal transduction, WNT, oxidative stress

Program affiliation
Plant and Microbial Biosciences
Computational and Systems Biology
Biomedical Informatics and Data Science

Research summary
The Mansfeld Lab uses various non‑model species and a hypothesis driven, systems approach to examine how circadian rhythm, development, and tissue type impact plant defense.

Key words
Plant Pathology, Genomics, Bioinformatics, Disease Resistance

Program affiliation
Computational and Systems Biology
Molecular Genetics and Genomics
Biomedical Informatics and Data Science

Research summary
Development of liquid biopsy approaches for brain tumors

Key words
liquid biopsy, cfDNA, genetics, epigenetics

Program affiliation
Molecular Genetics and Genomics
Computational and Systems Biology
Cancer Biology
Developmental Regenerative and Stem Cell Biology

Research summary
Understanding the molecular determinants of cellular diversity

Key words
Chromatin, Transcription Factors, Epigenomics, Cell fate, Single-cell

Program affiliation
Computational and Systems Biology
Molecular Genetics and Genomics

Research summary
Technology development for functional genomics and systems biology

Key words
functional genomics, systems biology, technology development, bioinformatics