Computational and Systems Biology

Program affiliation
Plant and Microbial Biosciences
Computational and Systems Biology
Biomedical Informatics and Data Science

Research summary
The Mansfeld Lab uses various non‑model species and a hypothesis driven, systems approach to examine how circadian rhythm, development, and tissue type impact plant defense.

Key words
Plant Pathology, Genomics, Bioinformatics, Disease Resistance

Program affiliation
Computational and Systems Biology
Molecular Genetics and Genomics
Biomedical Informatics and Data Science

Research summary
Development of liquid biopsy approaches for brain tumors

Key words
liquid biopsy, cfDNA, genetics, epigenetics

Program affiliation
Molecular Genetics and Genomics
Computational and Systems Biology
Cancer Biology
Developmental Regenerative and Stem Cell Biology

Research summary
Understanding the molecular determinants of cellular diversity

Key words
Chromatin, Transcription Factors, Epigenomics, Cell fate, Single-cell

Program affiliation
Plant and Microbial Biosciences
Computational and Systems Biology
Molecular Genetics and Genomics

Research summary
The function, biogenesis & evolution of small RNAs in plants

Key words

Program affiliation
Computational and Systems Biology
Molecular Genetics and Genomics

Research summary
Technology development for functional genomics and systems biology

Key words
functional genomics, systems biology, technology development, bioinformatics

Program affiliation
Computational and Systems Biology
Molecular Genetics and Genomics
Molecular Microbiology and Microbial Pathogenesis
Biochemistry Biophysics and Structural Biology

Research summary
Next-generation experimental, multi-omic and computational approaches to empower the study of infectious diseases and the human microbiome

Key words
Genomics of Infectious Diseases, Helminth Genomics, Human Metagenomics

Program affiliation
Molecular Genetics and Genomics
Computational and Systems Biology
Molecular Cell Biology

Research summary
Targeting Enteroendocrine Cell Development to Treat Metabolic Diseases

Key words
Genomics, Single-Cell, Endocrinology, Stem Cells, Gastroenterology, Intestine, Epigenetics

Program affiliation
Computational and Systems Biology
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
Systems and synthetic cell biology: quantitative analysis of cellular organization

Key words

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Computational and Systems Biology

Research summary
Understanding how mitochondria are built, regulated, and maintained

Key words
mitochondria, phosphorylation, metabolism, signaling, kinase, phosphatase

Program affiliation
Neurosciences
Developmental Regenerative and Stem Cell Biology
Computational and Systems Biology

Research summary
My research program aims to understand the neural circuits that underlie vocal communication processing and investigate how these circuits are disrupted in neuropsychiatric disorders.

Key words
Auditory System, Neuropsychiatric Disorders, Mouse Models, Communication Processing, Development