Computational and Systems Biology

Program affiliation
Computational and Systems Biology
Molecular Genetics and Genomics
Molecular Microbiology and Microbial Pathogenesis
Biochemistry Biophysics and Structural Biology

Research summary
Next-generation experimental, multi-omic and computational approaches to empower the study of infectious diseases and the human microbiome

Key words
Genomics of Infectious Diseases, Helminth Genomics, Human Metagenomics

Program affiliation
Molecular Genetics and Genomics
Computational and Systems Biology
Molecular Cell Biology

Research summary
Targeting Enteroendocrine Cell Development to Treat Metabolic Diseases

Key words
Genomics, Single-Cell, Endocrinology, Stem Cells, Gastroenterology, Intestine, Epigenetics

Program affiliation
Computational and Systems Biology
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
Systems and synthetic cell biology: quantitative analysis of cellular organization

Key words

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Computational and Systems Biology

Research summary
Understanding how mitochondria are built, regulated, and maintained

Key words
mitochondria, phosphorylation, metabolism, signaling, kinase, phosphatase

Program affiliation
Neurosciences
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Computational and Systems Biology
Immunology

Research summary

Key words

Program affiliation
Neurosciences
Developmental Regenerative and Stem Cell Biology
Computational and Systems Biology

Research summary
My research program aims to understand the neural circuits that underlie vocal communication processing and investigate how these circuits are disrupted in neuropsychiatric disorders.

Key words
Auditory System, Neuropsychiatric Disorders, Mouse Models, Communication Processing, Development

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Computational and Systems Biology

Research summary
We seek to understand the cellular and biochemical underpinnings of mitochondrial dysfunction in human diseases. Our work integrates large-scale methodologies with traditional biochemistry and cell biology to investigate the modulation, adaptation, and basic metabolic function of mitochondria.

Key words
Mitochondria, Protein biochemistry, Genetic screening, Metabolism, Biosynthesis, Orphan protein function, Proteomics, Metabolomics, Kinases and phosphates, Metabolic disease, Systems biochemistry

Program affiliation
Immunology
Computational and Systems Biology
Neurosciences

Research summary
Mechanisms of inflammation in immune-privileged organs

Key words

Program affiliation
Biochemistry Biophysics and Structural Biology
Computational and Systems Biology
Plant and Microbial Biosciences

Research summary
Biophysics of intrinsically disordered proteins

Key words
Huntington`s disease; Polyglutamine Aggregation; Intrinsically Disordered Proteins; Phase transitions in cell biology; Self-assembly; Transcriptional regulation; Small-scale Systems Biology & Interaction Networks;

Program affiliation
Neurosciences
Cancer Biology
Computational and Systems Biology

Research summary
Our lab employs cutting-edge molecular biology techniques to investigate the genetic, epigenetic, and cellular alterations driving the initiation, progression, and therapeutic resistance of brain tumors.

Key words
brain tumors, systems biology, genetics, neurosurgery, neurooncology