Developmental Regenerative and Stem Cell Biology
Jennifer Phillips-Cremins, PhD
BJC Investigator and James S. McDonnell Professor
- Email: jennifer.cremins@wustl.edu
Program affiliation
Molecular Genetics and Genomics
Neurosciences
Computational and Systems Biology
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Research summary
The Cremins lab integrates molecular and computational biology to elucidate how the genome’s structure-function relationship influences synaptic plasticity and neurophysiology during memory encoding and consolidation and how this goes awry in intractable neurological disorders.
Key words
chromatin, neuroepigenetics, 3D genome, synaptic plasticity, Alzheimer's, repeat expansion disorders, chromatin-synapse communication, neural connectome, organoids
Elizabeth Ann Pollina, PhD
Assistant Professor
- Email: pollina@wustl.edu
Program affiliation
Developmental Regenerative and Stem Cell Biology
Neurosciences
Molecular Genetics and Genomics
Molecular Cell Biology
Research summary
Molecular Mechanisms of Nervous System Longevity and Rejuvenation
Key words
epigenetics, nervous system, DNA repair, aging, rejuvenation
Sidharth Puram, MD, PhD
Lindburg Professor and Head of the Department of Otolaryngology
- Email: sidpuram@wustl.edu
Program affiliation
Molecular Genetics and Genomics
Cancer Biology
Computational and Systems Biology
Developmental Regenerative and Stem Cell Biology
Research summary
Understanding the role of tumor heterogeneity in cancer biology, including its contributions to cancer development, growth, metastasis, and treatment resistance mechanisms, in order to translate these insights into new diagnostics and novel therapeutics
Key words
tumor heterogeneity; single cell; spatial transcriptomics; head and neck cancer; signaling
Michael Rauchman, MDCM
Professor
- Email: mrauchma@wustl.edu
Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics
Research summary
Investigate gene regulation during kidney development and disease
Key words
Maria Remedi, PhD
Professor
- Email: mremedi@wustl.edu
Program affiliation
Molecular Cell Biology
Neurosciences
Developmental Regenerative and Stem Cell Biology
Research summary
Channels: diabetes, obesity and brain disorders
Key words
Diabetes, disease, channels, brain, neurons, hormones, growth, death, obesity, physiology
Stacey Rentschler, MD, PhD
Associate Professor
- Email: stacey.rentschler@wustl.edu
Program affiliation
Developmental Regenerative and Stem Cell Biology
Research summary
Direct reprogramming of cells into specialized cardiac conduction tissues
Key words
conduction system, reprogramming, heart development, Notch, arrhythmia, regenerative medicine, mouse models
Linda Richards, AO, FAA, FAHMS, PhD
Edison Professor of Neuroscience & Head of the Department of Neuroscience
- Email: neurosciencechair@wustl.edu
Program affiliation
Neurosciences
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics
Cancer Biology
Molecular Cell Biology
Research summary
The Brain Development and Disorders Laboratory investigates how long-range neural circuits are established in the brain, and how neural circuit plasticity affects the function of the cerebral cortex.
Key words
cognitive and behavioral neuroscience, developmental neurobiology, molecular and cellular neuroscience, neurogenetics, cerebral cortex, corpus callosum, glial development, neuronal development, brain wiring, agenesis
Eduardo Rosa-Molinar, PhD
Professor
Program affiliation
Cancer Biology
Neurosciences
Developmental Regenerative and Stem Cell Biology
Biomedical Informatics and Data Science
Research summary
Key words
David Rudnick, MD, PhD
Associate Professor
- Email: rudnick_d@wustl.edu
Program affiliation
Developmental Regenerative and Stem Cell Biology
Research summary
Molecular mechanisms of liver injury and regeneration
Key words
liver; regeneration; alpha 1 antitrypsin deficiency; liver disease; aflatoxin; acute liver failure; cell cycle; mouse models; epigenetics; metabolism
Philip Ruzycki, PhD
Assistant Professor
- Email: p.ruzycki@wustl.edu
Program affiliation
Molecular Genetics and Genomics
Developmental Regenerative and Stem Cell Biology
Biomedical Informatics and Data Science
Neurosciences
Computational and Systems Biology
Research summary
Key words