Developmental Regenerative and Stem Cell Biology
David Gutmann, MD, PhD
Donald O. Schnuck Family Professor
- Email: gutmannd@wustl.edu
Program affiliation
Neurosciences
Cancer Biology
Molecular Genetics and Genomics
Developmental Regenerative and Stem Cell Biology
Research summary
Leveraging neurogenetic disorders to study normal brain development, cancer, and autism
Key words
pediatric brain cancer, brain development, neuroimmunology, cancer neuroscience, autism, hiPSC engineering, genetically engineered mice
Carmen Halabi, MD, PhD
Associate Professor
- Email: chalabi@wustl.edu
Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Research summary
Understanding how the extracellular matrix (ECM) contributes to normal arterial development and how its disruptionleads to abnormal vascular development and disease
Key words
Vascular biology, extracellular matrix, elastin, aneurysms, hypertension
Claudia Han, PhD
Assistant Professor
- Email: claudiah@wustl.edu
Program affiliation
Immunology
Molecular Genetics and Genomics
Developmental Regenerative and Stem Cell Biology
Neurosciences
Research summary
The Han lab investigates microglia and brain macrophage phenotypes in neurodevelopmental and neurodegenerative contexts through the lens of epigenomics and transcriptomics.
Key words
microglia, neurodevelopment, epigenetics, transcriptomics, neurodegeneration
Erik Herzog, PhD
Viktor Hamburger Distinguished Professor
- Email: herzog@wustl.edu
Program affiliation
Neurosciences
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology
Biomedical Informatics and Data Science
Research summary
Molecular, cellular and circuit analysis of circadian rhythms in mammals
Key words
neurobiology, behavior, imaging, circadian rhythm, glia, brain cancer, potassium channels, neuropeptides, astrocytes, glioblastoma, cancer, developmental biology, computational modeling
Eric Huang, MD, PhD
Edward Mallinckrodt Professor and Chair of the Department of Pathology and Immunology
- Email: erichuang@wustl.edu
Program affiliation
Immunology
Neurosciences
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics
Research summary
Key words
Benjamin Humphreys, MD, PhD
Joseph Friedman Professor
- Email: humphreysbd@wustl.edu
Program affiliation
Developmental Regenerative and Stem Cell Biology
Computational and Systems Biology
Research summary
Define cell hierarchies in kidney injury and repair and thereby identify the critical cell types in kidney repair and fibrosis
Key words
Stem cells, regenerative medicine, scRNA-seq, scATAC-seq, spatial transcriptomics, fibrosis, gene editing, iPS cells
Shin-ichiro Imai, MD, PhD
Professor
- Email: imaishin@wustl.edu
Program affiliation
Developmental Regenerative and Stem Cell Biology
Neurosciences
Molecular Genetics and Genomics
Molecular Cell Biology
Research summary
Understanding the molecular mechanism of aging and longevity in mammals
Key words
aging, longevity, hypothalamus, metabolism, NAD biosynthesis, Sirt1, NAMPT, NAD World
Masatoshi Inoue, PhD
Assistant Professor
- Email: inoue.m@wustl.edu
Program affiliation
Neurosciences
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology
Research summary
Our research program integrates protein engineering and systems neuroscience to address previously inaccessible questions about brain function, particularly in the area of social behavior.
Key words
Social Behavior, Protein engineering, Optics, Neural dynamics, Genetically encoded optical tools
Sayaka Inoue, PhD
Assistant Professor
- Email: sayaka@wustl.edu
Program affiliation
Neurosciences
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Research summary
We aim to understand neural basis controlling behaviors in females across the lifespan
Key words
neurobiology, behavior, hormone, plasticity, maturation, aging, optogenetics, calcium imaging, and circuit tracing
Sanjay Jain, MD, PhD
Associate Professor
- Email: sjain22@wustl.edu
Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics
Biomedical Informatics and Data Science
Research summary
Interactions between the nervous and genitourinary systems during development, molecular basis for heterogeneity in progenitors and their lineage commitments in the GU tract, injury and regeneration using animal models, mechanisms of malformations using organoids from iPSCs
Key words
cell fate, gene expression, genomics, disease models, growth factor signaling, kidney, bladder, innervation, stem cells, organogenesis, nervous system development, birth defects