Immunology

Program affiliation
Immunology
Molecular Cell Biology
Neurosciences
Molecular Genetics and Genomics

Research summary
Understanding how immune cells and metabolic organs interact to maintain normal metabolism and to support adaptation to physiologic challenges

Key words
Immunometabolism, Mitochondria, White/beige/brown adipose tissue, Innate immunity, Macrophages, Obesity

Program affiliation
Biochemistry Biophysics and Structural Biology
Immunology

Research summary
The molecular basis of lung diseases and drug development using structural biology tools

Key words
biophysics, crystallography, molecular medicine, asthma, mucosal immunology, Alzheimer`s disease, endocytosis, receptor trafficking, structural biology, structure based drug design

Program affiliation
Immunology
Molecular Cell Biology
Molecular Genetics and Genomics
Developmental Regenerative and Stem Cell Biology
Molecular Microbiology and Microbial Pathogenesis

Research summary
The Brimble lab studies the secondary consequences of viral gene therapy approaches. We primarily interrogate T cell responses arising in patients who have received AAV gene therapy and nucleic acid impurities of viral vector systems. We are also developing novel viral vector delivery systems immunologically distinct from AAV vectors in current clinical use.

Key words
AAV Gene Therapy TCR viral vectors translational

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Immunology

Research summary
The research in my laboratory is aimed at understanding fundamental principles of the interaction between bacterial pathogens and the human host.

Key words

Program affiliation
Immunology
Molecular Cell Biology

Research summary
Our laboratory is interested in the role of platelets and leukocytes in inflammatory diseases which induce changes in hemostasis and thrombosis

Key words
thrombosis, platelets, stroke, neutrophils

Program affiliation
Immunology
Cancer Biology
Neurosciences

Research summary
We study the antigen specificity and function of CD8 T cells in the context of neurodegeneration and cancer

Key words
T cells, Amyotrophic Lateral Sclerosis, antigen specificity, cancer

Program affiliation
Immunology
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Biomedical Informatics and Data Science

Research summary
We study disease-relevant cell and organ signaling pathways in inflammatory bowel disease using molecular and cell biology, multi-omics technologies, genetic murine models, and patient samples.

Key words
inflammatory bowel disease, mucosal immunity, innate lymphoid cells, human intestinal organoids, regenerative medicine, biomarker discovery, cellular stress response, perianal fistulizing Crohn's disease, eosinophilic esophagitis, colon cancer

Program affiliation
Cancer Biology
Immunology
Molecular Genetics and Genomics
Developmental Regenerative and Stem Cell Biology

Research summary
Cancer stem cells, oncolytic viruses, and functional genomics of cancer

Key words
Cancer stem cells, oncolytic viruses, and functional genomics of cancer

Program affiliation
Molecular Cell Biology
Immunology
Biochemistry Biophysics and Structural Biology

Research summary
Understanding the mechanisms that regulate platelet and neutrophil activation and their homotypic and heterotypic interactions under thromboinflammatory conditions.

Key words
Platelet, Neutrophil, Thrombosis, Inflammation, Stroke, Sickle Cell Disease, Intravital microscopy

Program affiliation
Immunology
Molecular Cell Biology
Cancer Biology

Research summary
Understanding T cells and immunoregulatory networks in GvHD and GvL for the treatment of hematopoietic malignancies.

Key words
graft-versus-host disease (GvHD), graft-versus-leukemia (GvL), JAK-STAT, very-low-density lipoprotein receptor (VLDLR), protein kinase N1 (PKN1), immune cell trafficking, transplant immunology, CRISPR/Cas9