Immunology

Program affiliation
Developmental Regenerative and Stem Cell Biology
Immunology
Cancer Biology
Molecular Cell Biology

Research summary
Angioimmune interface in development, tissue regeneration, and cancer

Key words
Cell fate, transcription factors, hematopoiesis, vascular, development, regeneration, stem cells, tumor angiogenesis, tumor immunity

Program affiliation
Cancer Biology
Molecular Microbiology and Microbial Pathogenesis
Immunology

Research summary
Tryptophan metabolism and probiotic bacteria as modifiers of intestinal cancer and inflammation

Key words
tryptophan metabolism, intestinal inflammation, colitis associated cancer, colon cancer, mucositis, tryptophan, crohn, colitis, inflammatory bowel disease, radiation enteritis

Program affiliation
Immunology
Molecular Cell Biology

Research summary
The mechanisms regulating calcium-dependent neutrophil activation

Key words

Program affiliation
Immunology
Human and Statistical Genetics

Research summary
The Cooper laboratory is focused on investigating the molecular and immunologic basis of inborn errors of immunity. We are particularly interested in understanding novel genetic causes of these diseases in children with immune dysregulation syndromes.

Key words
inborn errors of immunity, genetics, primary immunodeficiency STAT3, TLR8, Pediatrics

Program affiliation
Immunology
Cancer Biology

Research summary
Circulating tumor cell biology, use of AI on digital histologic images to predict prognosis and response to therapy

Key words
Artificial Intelligence, Machine Learning, Digital Pathology, Circulating Tumor Cells, Response to Therapy,

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Molecular Genetics and Genomics
Immunology
Developmental Regenerative and Stem Cell Biology

Research summary
To address the central mandate of gene therapy we engineer adenovirus tropism to allow the achievement of effective gene delivery

Key words
Adenovirus, virotherapy, virus, cancer, gene therapy, vaccine

Program affiliation
Neurosciences
Cancer Biology
Immunology

Research summary
The primary research goal of our laboratory is to uncover novel ways to alter the pediatric brain tumor microenvironment to enhance the efficacy of existing treatments and make treatments safer for children.

Key words
brain tumors, cancer, neurology, immunology, imaging

Program affiliation
Neurosciences
Molecular Cell Biology
Immunology
Biochemistry Biophysics and Structural Biology

Research summary
Understanding the molecular and cellular mechanisms of protein aggregation and neurodegeneration in Parkinson disease and dementia with Lewy bodies

Key words
Parkinson disease, Lewy body dementia, REM sleep behavior disorder, synuclein, neurodegeneration, microglia, APOE, orexin

Program affiliation
Cancer Biology
Molecular Cell Biology
Immunology

Research summary
Molecular Mechanisms of Immune Regulation of Tumor Progression.

Key words
immunotherapy, breast cancer, pancreatic cancer, immunology, inflammation, metastasis, storm

Program affiliation
Immunology
Cancer Biology
Molecular Cell Biology

Research summary
The DeSelm Lab focuses on engineering immune cells with chimeric antigen receptors (CARs) to better understand tumor-immune interactions and develop next generation therapies for cancer, Alzheimer's Disease, and other incurable conditions.

Key words
Immunotherapy, cancer, CAR T-cells, CAR-DC1