Immunology

Program affiliation
Computational and Systems Biology
Immunology
Cancer Biology
Molecular Genetics and Genomics
Biomedical Informatics and Data Science

Research summary
My research interests lie in integrating and applying novel computational biology techniques with mechanistic experimental immunology to understand drivers of response and resistance to NK cell therapies for cancer

Key words
natural killer cells, computational biology, single-cell sequencing, immunotherapy, nk cells

Program affiliation
Biochemistry Biophysics and Structural Biology
Cancer Biology
Neurosciences
Immunology
Developmental Regenerative and Stem Cell Biology

Research summary
Small molecule drug discovery inspired research across multiple therapeutic areas including chronic pain, oncology, and neurodegeneration.

Key words
drug discovery, medicinal chemistry, chemical biology, synthetic methods

Program affiliation
Biochemistry Biophysics and Structural Biology
Immunology
Molecular Microbiology and Microbial Pathogenesis

Research summary
Mechanisms of host immunity and viral evasion

Key words
immunology, virology, structural biology, viral immune evasion, cytokine receptors, signaling, protein trafficking

Program affiliation
Biochemistry Biophysics and Structural Biology
Neurosciences
Immunology
Plant and Microbial Biosciences
Molecular Microbiology and Microbial Pathogenesis

Research summary
Dr. Fu’s research focuses on the structural and functional analysis of SPFH family proteins. Using cryo-electron microscopy and cryo-electron tomography, the Fu Lab studies membrane proteins in their native environments to explore their role in cellular signaling and disease

Key words
cryoem structure Ion channel membrane protein cryoet

Program affiliation
Immunology
Cancer Biology

Research summary
Development of a breast cancer vaccine

Key words
antigen presentation, breast cancer, translational research, T cells, vaccine

Program affiliation
Immunology
Molecular Cell Biology
Computational and Systems Biology

Research summary
Our research is dedicated to investigating the immunobiological pathways that underlie such pregnancy complications, with a special emphasis on preterm birth.

Key words
Immunology of Pregnancy, Maternal-fetal Immunology, In utero Inflammation, Preterm Birth

Program affiliation
Biomedical Informatics and Data Science
Cancer Biology
Molecular Cell Biology
Immunology

Research summary
Development of personalized medicine strategies for cancer using genomic technologies

Key words
bioinformatics, machine learning, cancer, genomics, immunogenomics, precision oncology

Program affiliation
Neurosciences
Molecular Cell Biology
Immunology

Research summary
We develop innovative magnetic resonance (MR) and position emission tomography (PET) imaging approaches to monitor neuroinflammation, neurodegeneration and repair mechanisms in neurological disorders

Key words
Metabolic imaging, hyperpolarized 13C MRI, positron tomography emission (PET) imaging, neurological disorders, cell tracking, multiple sclerosis, microglia, myelin, immune cells

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Immunology

Research summary
Application of stem cells and mechanobiology in the onset, progression, and treatment of osteoarthritis and other joint diseases.

Key words
cartilage, obesity, osteoarthritis, mechanobiology, bioengineering, stem cells, iPSCs

Program affiliation
Immunology
Molecular Genetics and Genomics
Developmental Regenerative and Stem Cell Biology
Neurosciences

Research summary
The Han lab investigates microglia and brain macrophage phenotypes in neurodevelopmental and neurodegenerative contexts through the lens of epigenomics and transcriptomics. 

Key words
microglia, neurodevelopment, epigenetics, transcriptomics, neurodegeneration