Neurosciences

Program affiliation
Developmental Regenerative and Stem Cell Biology
Neurosciences
Molecular Genetics and Genomics
Molecular Cell Biology

Research summary
Understanding the molecular mechanism of aging and longevity in mammals

Key words
aging, longevity, hypothalamus, metabolism, NAD biosynthesis, Sirt1, NAMPT, NAD World

Program affiliation
Neurosciences
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology

Research summary
Our research program integrates protein engineering and systems neuroscience to address previously inaccessible questions about brain function, particularly in the area of social behavior.

Key words
Social Behavior, Protein engineering, Optics, Neural dynamics, Genetically encoded optical tools

Program affiliation
Neurosciences
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology

Research summary
We aim to understand neural basis controlling behaviors in females across the lifespan

Key words
neurobiology, behavior, hormone, plasticity, maturation, aging, optogenetics, calcium imaging, and circuit tracing

Program affiliation
Cancer Biology
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Neurosciences

Research summary
Precision medicine through metabolism-based imaging and therapy: from laboratory to clinical translation

Key words
cancer, metabolism, imaging, sex differences, body composition

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Neurosciences

Research summary
Protein folding and misfolding, and the engineering and application of protein disaggregases to reverse misfolding

Key words
protein folding and misfolding; intrinsically disordered proteins, phase separation, and neurodegenerative disease; protein chaperones; protein engineering; amyloid; yeast models of protein misfolding

Program affiliation
Neurosciences
Molecular Genetics and Genomics
Molecular Cell Biology

Research summary
Cellular and molecular pathogenesis of Alzheimer's disease

Key words
Alzheimer's disease, neurodegeneration, amyloid, tau, mouse models, risk factors, lysosome, gene therapy

Program affiliation
Neurosciences
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology

Research summary
Understanding the molecular and cellular mechanisms underlying tauopathies

Key words
neurodegeneration, neurogenetics, Alzheimer`s disease, frontotemporal dementia, tau, amyloid precursor protein, induced pluripotent stem cells (iPSC), cell and molecular biology, molecular mechanisms

Program affiliation
Ecology and Evolutionary Biology
Neurosciences
Molecular Genetics and Genomics

Research summary
In the Kautt Lab, we combine a genomics-centered approach with molecular experiments, behavioral assays, and fieldwork to elucidate both the evolutionary and molecular mechanisms underlying organismal adaptation and diversification, with a focus on animal behavior.

Key words
Evolution, Genomics, Behavior, Adaptation, Speciation

Program affiliation
Neurosciences
Computational and Systems Biology

Research summary
Neurobiology of cognition, decision-making and applications to biological psychiatry. Brain-body interactions

Key words

Program affiliation
Neurosciences
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology

Research summary
Visual system neuroscience and vision restoration

Key words
physiology, imaging, behavior, genetic and viral engineering, human neuroscience, vision, repair, mathematical modeling