Neurosciences

Program affiliation
Molecular Genetics and Genomics
Neurosciences
Computational and Systems Biology
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology

Research summary
The Cremins lab integrates molecular and computational biology to elucidate how the genome’s structure-function relationship influences synaptic plasticity and neurophysiology during memory encoding and consolidation and how this goes awry in intractable neurological disorders.

Key words
chromatin, neuroepigenetics, 3D genome, synaptic plasticity, Alzheimer's, repeat expansion disorders, chromatin-synapse communication, neural connectome, organoids

Program affiliation
Neurosciences
Molecular Cell Biology

Research summary
Understanding the synaptic mechanisms by which emotional experiences lead to maladaptive plasticity and the impact of neurotherapeutic drugs on those maladaptive synaptic neuroadaptations

Key words
synaptic plasticity, Optogenetics, cell-type specific pharmacology, patch clamp electrophysiology, rapid-acting antidepressants, motivated behavior, drug addiction and affective disorders

Program affiliation
Developmental Regenerative and Stem Cell Biology
Neurosciences
Molecular Genetics and Genomics
Molecular Cell Biology

Research summary
Molecular Mechanisms of Nervous System Longevity and Rejuvenation

Key words
epigenetics, nervous system, DNA repair, aging, rejuvenation

Program affiliation
Neurosciences
Molecular Cell Biology

Research summary
My lab studies the molecular mechanisms of migraine chronicity, with an emphasis on opioid receptors

Key words
Opioids, pain, migraine, mouse models, neuroplasticity, addiction

Program affiliation
Neurosciences
Biomedical Informatics and Data Science

Research summary
The neuroscience of ASD, social cognition and comparative cognition

Key words
fcMRI, fMRI, infant, autism, face perception, visual attention, psychophysics, social cognition, comparative cognition

Program affiliation
Neurosciences

Research summary
Functional brain imaging with positron emission tomography and magnetic resonance

Key words
imaging, behavior, cognition, fMRI, PET

Program affiliation
Molecular Cell Biology
Neurosciences
Developmental Regenerative and Stem Cell Biology

Research summary
Channels: diabetes, obesity and brain disorders

Key words
Diabetes, disease, channels, brain, neurons, hormones, growth, death, obesity, physiology

Program affiliation
Immunology
Molecular Microbiology and Microbial Pathogenesis
Neurosciences

Research summary
Understanding the neuroimmune basis of infectious and non-infectious diseases

Key words
Pain and sensory disorders; Infectious diseases; Neuroimmunology; Host-microbe interactions

Program affiliation
Neurosciences
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics
Cancer Biology
Molecular Cell Biology

Research summary
The Brain Development and Disorders Laboratory investigates how long-range neural circuits are established in the brain, and how neural circuit plasticity affects the function of the cerebral cortex.

Key words
cognitive and behavioral neuroscience, developmental neurobiology, molecular and cellular neuroscience, neurogenetics, cerebral cortex, corpus callosum, glial development, neuronal development, brain wiring, agenesis

Program affiliation
Biochemistry Biophysics and Structural Biology
Computational and Systems Biology
Neurosciences

Research summary
To understand how and why membrane proteins fold, form stable complexes, and achieve conformational stability inside of the oil-filled cell membrane.

Key words
membrane protein; single-molecule; TIRF microscopy; protein folding; thermodynamics; lipids; oligomerization