Programs

Program affiliation
General

Research summary
We conduct social science research on ethical and social issues in medicine and biomedical research.

Key words
research ethics, bioethics, research integrity, qualitative research, surveys

Program affiliation
General

Research summary
My research focus is on the impact of obesity and diabetes on mitochondrial biogenesis and function.

Key words
obesity, diabetes, mitochondrial metabolism, nutrition

Program affiliation
Molecular Genetics and Genomics
Molecular Cell Biology
Human and Statistical Genetics
Plant and Microbial Biosciences

Research summary
The lab investigates the assembly and function of basal bodies/centrioles and cilia using genetics, biochemistry, microscopy, and computational biology in Chlamydomonas as well as human tissue culture cells. The key questions that we address are: 1.) how these microtubule-based structures are assembled, and 2.) how they function and influence cellular biology, development, and human health. Our interest in basal bodies/cilia led us to use bioinformatics and comparative genomics.

Key words
centrioles, cilia, signal transduction, cytoskeleton, lung disease

Program affiliation
Neurosciences

Research summary
Movement and Neurodegenerative Disease

Key words
gait, balance, Parkinson disease, motor control, movement, neurodegeneration, neuroimaging, neurorehabilitation

Program affiliation
Immunology
Molecular Microbiology and Microbial Pathogenesis
Molecular Genetics and Genomics

Research summary
Immune cell development and function

Key words
dendritic cells, macrophages, hematopoiesis, infection, inflammation, innate immunity, autoimmunity, multiple sclerosis

Program affiliation
Plant and Microbial Biosciences

Research summary
Using genetic approaches to understand the evolutionary and ecological causes and consequences of rarity in endangered plant species

Key words

Program affiliation
Computational and Systems Biology
Molecular Genetics and Genomics
Human and Statistical Genetics

Research summary
We develop new computational and experimental approaches to understand the roles of DNA methylation and hydroxymethylation in neurodevelopment and cancer

Key words
bioinformatics, cancer, cancer genomics, epigenetics, epigenomics, neurodevelopment, transcriptional regulation

Program affiliation
Immunology
Developmental Regenerative and Stem Cell Biology

Research summary
Gene regulation for lymphocyte development and adaptive immune responses

Key words
lymphocyte development, adaptive immunity, transcription factors, cytokines, oncogenesis

Program affiliation
Molecular Genetics and Genomics
Biochemistry Biophysics and Structural Biology
Neurosciences
Molecular Cell Biology

Research summary
We aim to understand how metabolism influences epigenetics, gene expression and behavior, particularly in the context of substance use disorders and neurodegeneration

Key words
Metabolism, epigenetics, alcohol, addiction, neurodegeneration, Alzheimer’s

Program affiliation
Neurosciences
Biochemistry Biophysics and Structural Biology

Research summary
Developing novel tools that extend mapping of brain function beyond current limitations

Key words
optical, autism, congenital heart disease, language, development, HD-DOT, ECMO, brain