Programs
R. Keith Slotkin, PhD
Full Member and Principal Investigator
- Email: r.keith@wustl.edu
Program affiliation
Plant and Microbial Biosciences
Molecular Genetics and Genomics
Research summary
Investigating how plant cells determine which fragments of DNA should be expressed (like genes), and which should be targeted for repression and not allowed to express
Key words
transposable element, epigenetics, DNA methylation, chromatin, transgene silencing
Adam Smith, PhD
Associate Scientist
- Email: adamsmith@wustl.edu
Program affiliation
Ecology and Evolutionary Biology
Research summary
Key words
Christopher Smyser, MD
Professor
- Email: smyserc@wustl.edu
Program affiliation
Neurosciences
Research summary
Investigating the effects of prematurity and other modifiable clinical and environmental risk factors on neurodevelopmental outcomes in high-risk pediatric populations
Key words
Neurodevelopment; neonate; prematurity; psychopathology; brain injury; MRI; structural connectivity; functional connectivity
Lawrence Snyder, MD, PhD
Professor
- Email: larry@eye-hand.wustl.edu
Program affiliation
Neurosciences
Research summary
Information processing in the cerebral cortex
Key words
behavior, cognition, computational biology, eye-hand coordination, neurophysiology, systems neuroscience
Lilianna Solnica-Krezel, PhD
Professor and Head of the Department of Developmental Biology
- Email: solnical@wustl.edu
Program affiliation
Developmental Regenerative and Stem Cell Biology
Research summary
Inductive and morphogenetic processes that establish and shape germ layers during vertebrate embryogenesis, using zebrafish and embryonic stem cell models
Key words
Gastrulation, Vertebrate embryogenesis, Patterning, Cell movement, Cell signaling, Morphogenesis, Stem Cells
Sheng-Kwei Song, PhD
Professor
- Email: ssong@wustl.edu
Program affiliation
Neurosciences
Research summary
Imaging CNS function and pathology
Key words
diffusion, imaging, multiple sclerosis, retinal degeneration, spinal cord, White matter injury
Andrea Soranno, PhD
Associate Professor
- Email: soranno@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Research summary
Role of disordered proteins in function and dysfunction: from Alzheimer's disease to SARS CoV 2
Key words
disordered proteins, single molecule, fluorescence, FRET, Alzheimer's disease, SARS CoV 2 nucleocapsid, Apolipoprotein E, ApoE, biomolecular condensates, polymer models
George Souroullas, PhD
Assistant Professor
- Email: george.souroullas@wustl.edu
Program affiliation
Cancer Biology
Molecular Genetics and Genomics
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology
Research summary
Understand how epigenetic mechanisms and chromatin dynamics contribute towards the development of cancer.
Key words
Epigenetics, chromatin, cancer, mouse models, lymphoma, melanoma, EZH2, PRC2, H3K27me3
David Spencer, MD, PhD
Associate Professor
- Email: dspencer@wustl.edu
Program affiliation
Molecular Genetics and Genomics
Cancer Biology
Developmental Regenerative and Stem Cell Biology
Computational and Systems Biology
Research summary
My research program studies DNA methylation in cancer, with a specific emphasis on understanding the origin, evolution, and functional impact of cancer-associated DNA methylation changes and how these can be used as biomarkers of clinical outcomes.
Key words
epigenetics, methylation, gene regulation, cancer, leukemia, genomics
Philip Stahl, PhD
Edward Mallinckrodt Jr Professor Emeritus
- Email: pstahl@wustl.edu
Program affiliation
General
Research summary
Exosomes- biogenesis and secretion. Hominoid-specific genes such as TBC1D3, that regulate growth factor receptor signaling, may help explain human evolution and physiology
Key words
Exosomes, endocytosis, hominoid-specific genes