Biochemistry Biophysics and Structural Biology

Program affiliation
Neurosciences
Biochemistry Biophysics and Structural Biology

Research summary
Okuno Lab investigates how water molecules interact with protein surfaces and explores the underlying mechanisms of protein folding and aggregation through NMR spectroscopy.

Key words
Biophysics, NMR, solvent, protein hydration, aggregation, reverse micelles

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Computational and Systems Biology

Research summary
We seek to understand the cellular and biochemical underpinnings of mitochondrial dysfunction in human diseases. Our work integrates large-scale methodologies with traditional biochemistry and cell biology to investigate the modulation, adaptation, and basic metabolic function of mitochondria.

Key words
Mitochondria, Protein biochemistry, Genetic screening, Metabolism, Biosynthesis, Orphan protein function, Proteomics, Metabolomics, Kinases and phosphates, Metabolic disease, Systems biochemistry

Program affiliation
Plant and Microbial Biosciences
Biochemistry Biophysics and Structural Biology
Molecular Genetics and Genomics

Research summary
Systems and Synthetic Biology of photosynthetic organisms

Key words
Bioenergy, membrane proteins, photosynthesis, redox processes, systems biology, synthetic biology

Program affiliation
Cancer Biology
Biochemistry Biophysics and Structural Biology
Immunology

Research summary
https://sites.wustl.edu/panlab/

Key words
Onco-Nephrology, Cardio-Oncology, Cancer, MRI, Gene/drug delivery, Machine Learning

Program affiliation
Biochemistry Biophysics and Structural Biology
Computational and Systems Biology
Plant and Microbial Biosciences

Research summary
Biophysics of intrinsically disordered proteins

Key words
Huntington`s disease; Polyglutamine Aggregation; Intrinsically Disordered Proteins; Phase transitions in cell biology; Self-assembly; Transcriptional regulation; Small-scale Systems Biology & Interaction Networks;

Program affiliation
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
We combine experimental measurements and computational modeling to understand how single and grouped respond to physical heterogeneities present in their extracellular microenvironments.

Key words
Mechanobiology; tumor invasion; cell migration; epithelial-mesenchymal transition; cell-matrix interaction; cytoskeleton;

Program affiliation
Cancer Biology
Computational and Systems Biology
Biochemistry Biophysics and Structural Biology
Biomedical Informatics and Data Science

Research summary
To understand the metabolic crosstalk between cells and tissues in disease models such as cancer by using isotopes and metabolomics

Key words
metabolism, metabolomics, mass spectrometry, bioinformatics, imaging, cancer, tumor microenvironment, isotope tracing

Program affiliation
Molecular Cell Biology
Molecular Microbiology and Microbial Pathogenesis
Biochemistry Biophysics and Structural Biology
Molecular Genetics and Genomics

Research summary
Identifying new targets and possible therapies to treat malaria

Key words
malaria, mRNA surveillance, drug discovery

Program affiliation
Biomedical Informatics and Data Science
Computational and Systems Biology
Biochemistry Biophysics and Structural Biology

Research summary
Translational Bioinformatics, Clinical Research Informatics

Key words
Biomedical Informatics, Data Science, Data Analytics, Clinical Research, Translational Research

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology

Research summary
EGF receptor-mediated cell signaling and the control of cell growth

Key words
signal transduction, cell signaling, cancer, EGF receptor