Kendall J. Blumer, Ph.D.
Cell Biology and Physiology
Molecular Cell Biology Program
506 McDonnell Medical Sciences Building
signal transduction, cancer, drug development
G protein-coupled receptor signaling in physiology and disease
Signal transduction by G protein coupled receptors (GPCRs) is the focus of our research. GPCRs are the largest and most important class of receptors in humans because they are the targets of more than half of all therapeutic agents. We are entering an exciting new phase of our work in which we are working to: 1) understand how palmitoylation, a reversible lipid modification, controls GPCR signal transduction in several biological and disease settings; and 2) develop inhibitors of specific G proteins, elucidate their mechanisms of action, and characterize their potential as therapeutic leads in cancer and other diseases. Both projects employ multidisciplinary approaches including biophysics, biochemistry, molecular biology, molecular and cellular imaging, pharmacology, and mouse physiology.
Osei-Owusu, P., Owens, E.A., Jie, L., Reis, J.S., Forrester, S.J., Kawai, T., Eguchi, S., Singh, H., & Blumer, K.J. (2015). Regulation of Renal Hemodynamics and Function by RGS2. PLoS One 10(7):e0132594.
Rensing, D.T., Uppal, S., Blumer, K.J., & Moeller K.D. (2015). Toward the Selective Inhibition of G Proteins: Total Synthesis of a Simplified YM-254890 Analog. Org Lett. 17(9):2270-3
Jia, L, Chisari, M., Maktabi, M.H., Sobieski, C., Zhou, H., Konopko, A.M., Martin, B.R., Mennerick, S.J., & Blumer, K.J. (2014). A mechanism regulating G protein-coupled receptor signaling that requires cycles of protein palmitoylation and depalmitoylation. J Biol Chem. 289(9):6249-57
Cain, M.D, Vo, B.Q., Kolesnikov, A.V., Kefalov, V.J., Culican, S.M., Kerschensteiner, D., & Blumer, K.J. (2013). An allosteric regulator of R7-RGS proteins influences light-evoked activity and glutamatergic waves in the inner retina. PLoS One. 8(12):e82276
Zhou, H., Chisari, M., Raehal, K.M., Kaltenbronn, K.M, Bohn L.M., Mennerick, S.J., & Blume, K.J. (2012). GIRK channel modulation by assembly with allosterically regulated RGS proteins. Proc Natl Acad Sci U S A. 109(49):19977-82
Osei-Owusu, P., Sabharwal, R., Kaltenbronn, K.M., Rhee, M.H., Chapleau, M.W., Dietrich, H.H., & Blumer, K.J. (2012). Regulator of G protein signaling 2 deficiency causes endothelial dysfunction and impaired endothelium-derived hyperpolarizing factor-mediated relaxation by dysregulating Gi/o signaling.
J Biol Chem. 287(15):12541-9
Jia L., Linder, M.E., & Blumer, K.J. (2011). Gi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein. J Biol Chem. 286(15):13695-703
Last Updated: 4/18/2016 10:26:49 AM