Andrew C. Heath, D.Phil.

Spencer T. Olin Professor of Psychology
Psychiatry
Professor
Genetics
Psychological and Brain Sciences

Human and Statistical Genetics Program
Evolution, Ecology and Population Biology Program

  • 314-286-2203

  • 314-286-2213

  • 8134

  • 4560 Clayton Ave., Suite 1000, St. Louis, MO 63110

  • aheath@wustl.edu

  • http://www.alcoholdependence.org

  • substance abuse, development, modeling, psychiatry, quantitative genetics

  • Genetic studies of alcoholism, smoking and drug dependence, depression, suicidality and anxiety disorders, personality disorders, and methodological research in genetic epidemiology

Research Abstract:

Our research is focused on understanding genetic and environmental contributions to risk of psychiatric disorder (especially alcoholism and substance abuse, affective disorder, personality disorders, disorders of childhood and adolescence), and to normal behavioral variation (e.g. personality and temperament, smoking and drinking habits). Data from twin pairs and other relatives are used to dissect the joint effects of genes and environment, their covariation and interaction.

Research projects include: theoretical and simulation projects focused on issues of multivariate analysis and the genetic analysis of developmental phenomena; data-analysis projects using large (N>50,000 subjects) twin-family data sets from Australia and the U.S.; data collection using the Missouri Twin Register, a register of all twin pairs born in Missouri from 1968 onwards, focused on attention deficit/hyperactivity disorder and adolescent alcohol and drug problems; and, data collection to study the genetic contribution to risk of alcoholism and other psychiatric disorders, using two large Australian twin cohorts.

Selected Publications:

Lynskey MT, Heath AC, Bucholz KK, et al. Escalation of drug use in early-onset cannabis users versus co-twin controls. JAMA 2003 289:427-433.

Dinwiddie SH, Heath AC, Dunn MP. Early sexual abuse and lifetime psychopathology: A cotwin-control study. Psychol Med 2000 30:41-52.

Heath AC, Madden PAF, Bucholz KK, et al. Genetic differences in alcohol sensitivity and the inheritance of alcoholism risk. Psychol Med 1999 29:1069-1081.

Statham DJ, Heath AC, Madden PAF, et al. Suicidal behaviour: An epidemiologic and genetic study. Psychol Med 1998 38:839-855.

Heath AC, Bucholz KK, Madden PAF, et al. Genetic and environmental contributions to alcohol dependence risk in a national twin sample: Consistency of findings in men and women. Psychol Med 1997 27:1381-1396.

Last Updated: 8/4/2011 9:40:31 AM

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