Gregory D. Longmore, M.D.
Professor
Internal Medicine
Molecular Oncology
Cell Biology and Physiology
Molecular Cell Biology Program
Developmental, Regenerative and Stem Cell Biology Program
Immunology Program
314-362-8834
314-362-8825
8069
ICCE Institute, BJC-IH Building, 7th Floor, Room 7627
glongmor@dom.wustl.edu
http://www.icce-wustl.org/
cell motility, cancer metastasis, cell adhesion, signal transduction
Cell Motility and Cancer Metastasis
Research Abstract:
The goal of my laboratory is to identify and understand how environmental cues regulate the movement of cells throughout the body. The major disease we investigate is cancer metastasis - how do tumor cells communicate with their environment to invade, migrate leading to metastasis. To do so use a multidisciplinary approaches through expertise in my lab (molecular cell biology, model organisms, imaging) or long-standing, cooperative, and productive collaborations with investigators at Washington University and other institutions (biophysics, mathematical modeling, structural chemistry). My laboratory is located in the ICCE Institute (Integration of Communication within the Cancer Environment), of the Siteman Cancer Center, where I am the Director. The ICCE Institute is located in the new BJC Institute for Health building and is dedicated to determining how interactions between tumor cells and their cellular and structural microenvironment facilitate tumor progression and metastasis.
Selected Publications:
Loza AJ, Koride S, Schimizzi GV, Li B, Sun SX, Longmore GD. Cell Density and actomyosin contractility control the organization of migrating collectives within an epithelium.
Mol. Biol. Cell in press, 2016.
Corsa C.A., Brenot A., Ponik S., Liu Y., Zhang K., Van Hove S., Eliceiri K.W., Denardo, D., Keely P.J. and G.D. Longmore. The action of discoidin domain receptor 2 in both basal breast tumor cells and stromal cells is critical for breast cancer metastasis. Cell Rep. 15(11):2510-23, 2016.
Zhang, K., Grither, W.R., Van Hove, S., Biswas, H., Ponik, S.M., Eliceiri, K.W., Keely, P.J., and G.D. Longmore. Mechanical signals stabilize and activate SNAIL1 in CAFs to control fibrogenic response.
J. Cell Sci. 129(10):1989-2002, 2016.
Jagannathan R., Schimizzi G.V., Zhang K., Loza A.J., Yabuta N., Nojima H. and
G.D. Longmore. AJUBA LIM proteins limit Hippo activity only in proliferating
cells by sequestering a cytosolic Hippo core kinase complex
Mol. Cell. Biol. July 25, 2016.
Fraley, S., Wu, P., He, L., Feng, Y., Krishnamurthy, R., Longmore, G.D. and D. Wirtz. Three-dimensional matrix fiber alignment modulates cell migration and MT1-MMP utility by spatially and temporally directing protrusions.
Science Rep. Oct. 1;5:14580, 2015.
Schimizzi G.V. and G.D. Longmore. Ajuba proteins. Curr Biol. 25(11):R445-6, 2015
Tran, H., K. Luitel, M. Kim, K. Zhang, G.D. Longmore, and D.D. Tran. Transient Snail1 Expression is Necessary for Efficient Breast Cancer Metastasis.
Cancer Res. 74(21):6330-40, 2014.
Yashiro H, A.J. Loza, J.B. Skeath, G.D. Longmore. Rho1 regulates adherens junction remodeling by promoting recycling endosome formation through activation of Myosin II. Mol. Biol. Cell. 25(19):2956-69, 2014
Zhang K, Corsa CA, Ponik SM, Prior JL, Piwnica-Worms D, Eliceiri KW, Keely PJ, and G.D. Longmore. The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis.
Nat Cell Biol. Jun;15(6):677-87, 2013.
Fraley, S.I., Y. Feng, A. Giri, G.D. Longmore and D. Wirtz. Dimensional and temporal controls of three-dimensional cell migration by zyxin and binding partners.
Nat. Commun. Mar 6;3:719, 2012.
Last Updated: 9/22/2016 8:50:14 AM