Gregory D. Longmore, M.D.

Professor
Internal Medicine
Molecular Oncology
Cell Biology and Physiology

Cancer Biology Program
Molecular Cell Biology Program
Developmental, Regenerative and Stem Cell Biology Program
Immunology Program

  • 314-362-8834

  • 314-362-8825

  • ICCE Institute, BJC-IH Building, 7th Floor, Room 7627

  • glongmor@dom.wustl.edu

  • http://www.icce-wustl.org/

  • cell motility, cancer metastasis, cell adhesion, signal transduction

  • Cell Motility and Cancer Metastasis

Research Abstract:

The goal of my laboratory is to identify and understand how environmental cues regulate the movement of cells about the body during development and disease states. The major disease states we investigate are cancer metastasis and organ fibrosis. To do so we study epithelial morphogenesis (EMT), cell adhesion and migration, and mechanobiology using multidisciplinary approaches through expertise in my lab (molecular cell biology, model organisms, cellular and animal imaging) or long-standing, cooperative, and productive collaborations with investigators at my institution and other institutions (biophysics, engineering, structural chemistry, computational modeling). My laboratory is located in the ICCE Institute (Integration of Communication within the Cancer Environment), of the Siteman Cancer Center at Washington University, where I am the Director. The Institute is dedicated to determining how interactions between tumor cells and their cellular, chemical, and structural microenvironment facilitate tumor progression and metastasis. I also co-direct one of the research programs (basic sciences) at the Siteman Cancer Center of Washington University. I have been fortunate in that @80% of graduate students and over half the postdoctoral fellows I have trained or am currently training have obtained individual, competitive, fellowship support (ACS, AHA, NIH/NCI, HHMI, NSF).

Selected Publications:

Sewell-Loftin MK, Katz JB, George SC, Longmore GD. Micro-strains in the extracellular matrix induce angiogenesis. Lab on a Chip 2020. Aug 7;20(15):2776-2787. PMID: 32614340

Yang J. et al., Guidelines and definitions for research on epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol. 2020 Jun;21(6):341-352.
PMID: 32300252

Bayer SV, Grither WR, Brenot A, Hwang PY, Barcus CE, Ernst M, Pence P, Walter C, Pathak A, Longmore GD. DDR2 controls breast tumor stiffness and metastasis by regulating integrin mediated mechanotransduction in CAFs.
Elife. 2019 May 30;8.

Hwang PY, Brenot A, King AC, Longmore GD, George SC. Randomly Distributed K14+ Breast Tumor Cells Polarize to the Leading Edge and Guide Collective Migration in Response to Chemical and Mechanical Environmental Cues.
Cancer Res. 2019 Apr 15;79(8):1899-1912. G. Longmore - communicating author

Grither WR, Divine LM, Meller EH, Wilke DJ, Desai RA, Loza AJ, Zhao P, Lohrey A, Longmore GD, Fuh KC. TWIST1 induces expression of discoidin domain receptor 2 to promote ovarian cancer metastasis.
Oncogene. 2018 Mar;37(13):1714-1729

Grither WR and Longmore GD. Inhibition of tumor-microenvironment interaction and tumor invasion by small-molecule allosteric inhibitor of DDR2 extracellular domain.
Proc Natl Acad Sci U S A. 2018 Aug 14;115(33): E7786-E7794.

Loza AJ, Koride S, Schimizzi GV, Li B, Sun SX, Longmore GD. Cell Density and actomyosin contractility control the organization of migrating collectives within an epithelium.
Mol. Biol. Cell Nov 7;27(22):3459-3470, 2016.

Corsa C.A., Brenot A., Ponik S., Liu Y., Zhang K., Van Hove S., Eliceiri K.W., Denardo, D., Keely P.J. and G.D. Longmore. The action of discoidin domain receptor 2 in both basal breast tumor cells and stromal cells is critical for breast cancer metastasis. Cell Rep. 15(11):2510-23, 2016.

Zhang, K., Grither, W.R., Van Hove, S., Biswas, H., Ponik, S.M., Eliceiri, K.W., Keely, P.J., and G.D. Longmore. Mechanical signals stabilize and activate SNAIL1 in CAFs to control fibrogenic response.
J. Cell Sci. 129(10):1989-2002, 2016.




Last Updated: 3/22/2021 10:05:39 AM

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