Erik D. Herzog, Ph.D.

Professor
Biology

Neurosciences Program
Molecular Cell Biology Program
Developmental, Regenerative and Stem Cell Biology Program

  • 314-935-8635

  • 314-935-5214

  • 314-935-4432

  • 1137

  • 205 Monsanto Laboratory

  • herzog@wustl.edu

  • http://pages.wustl.edu/herzog

  • neurobiology, physiology, behavior, imaging, circadian rhythm, olfaction, gliotransmission, brain cancer, potassium channels, computational modeling

  • Cellular and molecular analysis of circadian rhythms in mammals

Research Abstract:

Our laboratory studies the cellular and molecular bases for circadian rhythms in mammals. We seek to understand the roles of defined brain regions and classes of neurons and glia in the generation and coordination of circadian rhythms in physiology and behavior. Among our objectives, we aim to identify pacemaking cells, the mechanisms that synchronize their activities to each other, and the the signals they use to communicate time-of-day information to the rest of the brain and body. We take advantage of long-term, real-time recording technologies including multimicroelectrode arrays to monitor neuronal firing patterns, bioluminescence imaging of gene expression, and novel behavioral assays. Some of our findings may have relevance to causes of and treatments for mood disorders and pediatric brain cancers.

Selected Publications:

Abel JH, Meeker K, Granados-Fuentes D, St John PC, Wang TJ, Bales BB, Doyle FJ 3rd, Herzog ED, Petzold LR (2016) Functional network inference of the suprachiasmatic nucleus. Proc Natl Acad Sci U S A. 113:4512-7.

Mazuski C, Herzog ED ( 2015) Circadian rhythms: to sync or not to sync. Curr Biol. 25(8):R337-9.PMID: 25898105

Miller JE, Granados-Fuentes D, Wang T, Marpegan L, Holy TE, Herzog ED (2014) Vasoactive intestinal polypeptide mediates circadian rhythms in mammalian olfactory bulb and olfaction. J Neurosci. 34(17):6040-6.

GABA Networks Freeman GM Jr, Krock RM, Aton SJ, Thaben P, Herzog ED (2013) Destabilize Genetic Oscillations in the Circadian Pacemaker. Neuron 78:799-806.

Granados-Fuentes D, Norris AJ, Carrasquillo Y, Nerbonne JM, Herzog ED. I(A) Channels Encoded by Kv1.4 and Kv4.2 Regulate Neuronal Firing in the Suprachiasmatic Nucleus and Circadian Rhythms in Locomotor Activity. J Neurosci. 2012 18;32:10045-52

Webb AB, Taylor SR, Thoroughman KA, Doyle FJ 3rd, Herzog ED. Weakly circadian cells improve resynchrony. PLoS Comput Biol. 2012;8(11):e1002787.

Freeman GM Jr, Herzog ED. Neuropeptides go the distance for circadian synchrony. Proc Natl Acad Sci U S A. 2011 108:13883-4. PMC3161583

Marpegan L, Swanstrom AE, Chung K, Simon T, Haydon PG, Khan SK, Liu AC, Herzog ED, Beaule C. Circadian regulation of ATP release in astrocytes. J Neurosci. 2011 31:8342-50.

Webb, AB, Angelo N, Huettner JE and Herzog ED. Intrinsic, nondeterministic circadian rhythm generation in identified mammalian neurons. Proc Nat Acad Sci 2009 106:16493-8.

Marpegan L, Krall TJ, Herzog ED. Vasoactive intestinal polypeptide entrains circadian rhythms in astroctyes. J Biol Rhythms 2009 24: 135-43.

Herzog ED. Neurons and networks in daily rhythms. Nat Rev Neurosci. 2007 8: 790-802.

Aton SJ, Herzog ED. Come together, right…now: synchronization of rhythms in a mammalian circadian clock. Neuron. 2005 48:531-4.

Last Updated: 8/25/2016 8:42:30 AM

To coordinate the timing of many circadian oscillators, the brain uses synchronizing and desynchronizing signals.
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