Deanna Barch, Ph.D.

Professor and Chair
Psychological and Brain Sciences
Psychiatry
Radiology

Neurosciences Program

  • 314-935-8729

  • 314-935-8459

  • 314-935-8181

  • 314-935-8790

  • 1125

  • One Brookings Drive

  • dbarch@wustl.edu

  • http://ccpweb.wustl.edu//

  • cognition, neuroimaging, prefrontal cortex, psychiatry, schizophrenia, depression

  • Neurobiological and Psychological Mechanisms of Cognitive and Emotional Control: Normative Function and Abnormalities in Psychiatric Disorders

Research Abstract:

My program of research is focused on understanding the interplay among cognition, emotion, and brain function to better understand the deficits in behavior and cognition found in a range of populations. These include psychiatric disorders such as schizophrenia and depression. There are several major themes guiding my work. One theme has been the contribution that cognitive control deficits make to memory, thought and language disturbances in schizophrenia. By cognitive control I mean the collection of processes involved in guiding behavior in accordance with internal as well as external goals. A second theme has been to determine the neurobiological mechanisms (i.e., prefrontal cortex and dopamine deficits) that may underlie such cognitive control deficits. A third focus is the search to understand the relationship between cognitive and emotional deficits in disorders such as schizophrenia and depression. In trying to address these issues, my work has involved both basic research designed to understand how cognitive and emotional systems normally work and clinical research focused on how and why cognitive and emotional processing can go awry.

Selected Publications:

Barch, D. M., Burgess, G. C., Harms, M. P. Petersen, S. E., Schlaggar, B. L., Corbetta, M. Curtiss, S., Dixit, S., Feldt, C., Nolan, D., Bryant, E., Hartley, T., Footer, O., Bjork, J. M., Poldrack, R., Smith, S., Snyder, A. Z., Van Essen, D. C. (in press). The functional relevance of the Human Connectome: Task evoked fMRI and individual differences in behavior. Neuroimage.

Harms, M. P., Wang, L., Csernansky, J. G., & Barch, D. M. (2013). Structure-function relationship of working memory activity with hippocampal prefrontal cortex volumes. Brain Structure and Function, 218, 173-186. PMID: 22362200

Suzuki, H., Botteron, K. N., Luby, J. L., Belden, A. C., Gaffrey, M. S., Babb, C. M., Nishino, T., Miller, M. J., Ratnanather, J. T., Barch, D. M. (2013). Structural-functional correlations between hippocampal volume and cortico-limbic emotional responses in depressed children. Cognitive, Affective and Behavioral Neuroscience, 13, 135-151. PMCID: PMC3557609

Repovs, G. and Barch, D. M. (2012). Working memory related brain network connectivity in individuals with schizophrenia and their siblings. Frontiers in Neuroscience, 6, 137, 1-15. PMCID: PMC3358772

Dowd, E., & Barch, D. M. (2012). Reward anticipation and receipt during Pavlovian conditioning in schizophrenia: Relationship to anhedonia. PLOS One, 7, e35622. PMCID: PMC3344823

Gaffrey, M. S., Luby, J. L., Botteron, K., Repovs, G., & Barch, D. M. (2012). Default mode network connectivity in children with a history of preschool onset depression. Journal of the Academy of Child Psychiatry, 9, 964-972. PMCID: PMC3437619

Becerril, K. E., Repovs, G., & Barch, D. M. (2011). Error processing network dynamics in schizophrenia. Neuroimage, 54, 1495-1505. PMCID: PMC2997133

Cole, M. W., *Anticevic, A., Repovs, G., & Barch, D. (2011). Localizing global dysconnectivity: Dorsolateral prefrontal connectivity correlates with the cardinal symptoms of schizophrenia. Biological Psychiatry, 70, 43-50. PMCID: PMC3204885

Gaffrey, M. S., Luby, J. L., Belden, A. C., Hirshberg, J. S., Volsch, J., & Barch, D. M. (2011). Association between depression severity and amygdala reactivity during sad face viewing in depressed preschoolers: An fMRI study. Journal of Affective Disorders, 129, 364-370. PMCID: PMC3029507

Repovs, G., Csernansky, J. G., & Barch, D. M. (2011). Brain network connectivity in individuals with schizophrenia and their siblings. Biological Psychiatry, 69, 967-973. PMCID: PMC3081915

Last Updated: 7/29/2013 2:24:43 PM

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