Weixiong Zhang, Ph.D.

Professor
Computer Science and Engineering
Genetics

Computational and Systems Biology Program
Molecular Genetics and Genomics Program
Plant and Microbial Biosciences Program

  • 314-935-8788

  • 314-935-7302

  • 1045

  • 506 Jolley Hall

  • zhang@cse.wustl.edu

  • http://www.cse.wustl.edu/~zhang

  • Alzheimer’s disease, computational biology, plant biology, small noncoding RNAs, systems biology, transcriptional regulation

  • Computational approaches to elucidating transcriptional and post-transcriptional gene regulation underlying complex human diseases and plant stress tolerance

Research Abstract:

I am interested in developing novel machine learning and datamining approaches, algorithms and software tools for understanding the mechanism of transcriptional and post-transcriptional gene expression regulation. In my lab, we have been developing efficient computational methods for discovering cis-regulatory elements (motifs), constructing and characterizing functional networks of gene expression regulation, and identifying coding and non-coding genes that are responsive to particular stresses. I am particularly interested in applying computational methods to the study of complex human diseases, e.g., Alzheimer's disease, and of plant abiotic stress regulation and tolerance.

Selected Publications:

Webster JA, Cibbs JR, Clarke J, Ray M, Zhang W, Holmans P, Rohrer K, Zhao A, LMarlowe L, Kaleem M, McCorquodale III DS, Cuello C, Leung D, Bryden L, Nath P, Zisman VL, Joshipura K, Huentelman MJ, Lince DH, Coon KD, D.W. Craig DW, J.V. Pearson JV, C.B. Heward CB, E.M. Reiman EM, D. Stephan D, J. Hardy J, A.J. Myers AJ. Genetic control of human brain transcript expression in Alzheimer's disease. American J. of Human Genetics2009 84:445-4589.

Zhou X, Sunkar R, Jin H, Zhu J-K and Zhang W. Genome-wide identification and analysis of small RNAs originated from natural antisense transcripts in Oryza sativa. Genome Research 2009 19:70-8.

Ray M, Ruan J and Zhang W. Variations in the transcriptome of Alzheimer's disease reveal modular networks involved in cardiovascular diseases, Genome Biology 2008 9(10):R148.

Zhou X, Ruan J, Wang G and Zhang W. Characterization and identification of core promoters of microRNA genes of four model species. PLoS Computational Biology 2007 3(3):e37.

Wang G and Zhang W. A steganalysis-based approach to comprehensive identification and characterization of functional regulatory elements. Genome Biology, 2006 7(6):R49.

Last Updated: 8/4/2011 1:30:12 PM

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