Nancy L. Saccone, Ph.D.

Associate Professor
Genetics
Human Genetics

Human and Statistical Genetics Program
Molecular Genetics and Genomics Program
Computational and Systems Biology Program

  • 314-747-3263

  • 314-362-7088

  • 8232

  • 308A Biotechnology Building

  • nlims@wustl.edu

  • genetics, substance dependence, addiction, human disease gene mapping, association studies, linkage analysis

  • Statistical genetics, complex human diseases, analysis methods

Research Abstract:

My research uses mathematical and statistical methods to study the genetics of complex traits in humans. Methods under development include use of linkage disequilibrium (LD) structure in the design and interpretation of genetic association studies (e.g. tag SNP selection; leveraging LD differences in diverse populations to refine association signals). Applied projects focus on substance dependence and other complex diseases. To increase power to detect and characterize genetic factors, we conduct collaborative meta-analyses. To explain more of the risk for disease, we are also developing alternative phenotypes and studying gene-gene and gene-environment interactions.

Selected Publications:

Saccone NL, Culverhouse RC, Schwantes-An TH, Cannon DS, Chen X, Cichon S, Giegling I, Han S, Han Y, Keskitalo-Vuokko K, Kong X, Landi MT, Ma JZ, Short SE, Stephens SH, Stevens VL, Sun L, Wang Y, Wenzlaff AS, Aggen SH, Breslau N, Broderick P, Chatterjee N, Chen J, Heath AC, Heliövaara M, Hoft NR, Hunter DJ, Jensen MK, Martin NG, Montgomery GW, Niu T, Payne TJ, Peltonen L, Pergadia ML, Rice JP, Sherva R, Spitz MR, Sun J, Wang JC, Weiss RB, Wheeler W, Witt SH, Yang BZ, Caporaso NE, Ehringer MA, Eisen T, Gapstur SM, Gelernter J, Houlston R, Kaprio J, Kendler KS, Kraft P, Leppert MF, Li MD, Madden PA, Nöthen MM, Pillai S, Rietschel M, Rujescu D, Schwartz A, Amos CI, Bierut LJ. Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD. PloS Genet 2010 Aug 5;6(8). pii: e1001053.

Saccone NL, Schwantes-An T-H, Wang J-C, Grucza RA, Breslau N, Hatsukami D, Johnson EO, Rice JP, Goate AM, Bierut LJ. Multiple nicotinic receptor genes affect nicotine dependence risk in African and European Americans. Genes, Brain and Behavior 2010 9:741-750.

Saccone NL, Wang JC, Breslau N, Johnson EO, Hatsukami D, Saccone SF, Grucza RA, Sun L, Duan W, Budde J, Culverhouse RC, Fox L, Hinrichs AL, Steinbach JH, Wu M, Rice JP, Goate AM, Bierut LJ. The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. Cancer Research 2009 69: 6848-6856.

Saccone NL, Saccone SF, Goate AM, Grucza RA, Hinrichs AL, Rice JP, Bierut LJ. In search of causal variants: refining disease association signals using cross-population contrasts. BMC Genetics 2008 9: 58.

Saccone SF, Saccone NL, Swan GE, Madden PAF, Goate AM, Rice JP, Bierut LJ. Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence. Bioinformatics 2008 24: 1805-1811.

Saccone SF, Rice JP, Saccone NL. Power-based, phase-informed selection of single nucleotide polymorphisms for disease association screens. Genet Epidemiol 2006 30: 459-470.

Last Updated: 12/20/2011 11:41:59 AM

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