Nancy L. Saccone, Ph.D.

Associate Professor
Genetics
Human Genetics

Human and Statistical Genetics Program
Molecular Genetics and Genomics Program
Computational and Systems Biology Program

  • 314-747-3263

  • 8232

  • FLTC Suite 601

  • nlims@wustl.edu

  • genetics, substance dependence, addiction, human disease gene mapping, association studies, linkage analysis

  • Statistical genetics, complex human diseases, analysis methods

Research Abstract:

My research program uses mathematical and statistical methods to understand human genetic variation and its contribution to complex diseases and traits. Research areas include the impact of linkage disequilibrium (LD) and haplotype structure on the design and interpretation of genetic mapping studies, extending genetic studies to under-studied and minority populations, and increasing power to detect genetic loci, e.g. through collaborative meta-analyses. Applied projects focus on addiction, psychiatric disease, and other complex traits.

Selected Publications:

http://www.ncbi.nlm.nih.gov/sites/myncbi/nancy.saccone.1/bibliography/44075955/public/?sort=date&direction=descending

Saccone NL, Emery LS, Sofer T, Gogarten SM, Becker DM, Bottinger EP, Chen L-S, Culverhouse RC, Duan W, Hancock DB, Hosgood HD, Johnson EO, Loos RJF, Louie T, Papanicolaou G, Perreira KM, Rodriquez EJ, Schurmann C, Stilp AM, Szpiro AA, Talavera GA, Taylor KD, Thrasher JF, Yanek LR, Laurie CC, Pérez-Stable EJ, Bierut LJ, Kaplan RC (2017). Genome-wide association study of heavy smoking and daily/nondaily smoking in the Hispanic Community Health Study / Study of Latinos (HCHS/SOL). Nicotine and Tobacco Research, published online May 17, 2017.

Schwantes-An TH, Zhang J, Chen LS, Hartz SM, Culverhouse RC, Chen X, Coon H, Frank J, Kamens HM, Konte B, Kovanen L, Latvala A, Legrand LN, Maher BS, Melroy WE, Nelson EC, Reid MW, Robinson JD, Shen PH, Yang BZ, Andrews JA, Aveyard P, Beltcheva O, Brown SA, Cannon DS, Cichon S, Corley RP, Dahmen N, Degenhardt L, Foroud T, Gaebel W, Giegling I, Glatt SJ, Grucza RA, Hardin J, Hartmann AM, Heath AC, Herms S, Hodgkinson CA, Hoffmann P, Hops H, Huizinga D, Ising M, Johnson EO, Johnstone E, Kaneva RP, Kendler KS, Kiefer F, Kranzler HR, Krauter KS, Levran O, Lucae S, Lynskey MT, Maier W, Mann K, Martin NG, Mattheisen M, Montgomery GW, Müller-Myhsok B, Murphy MF, Neale MC, Nikolov MA, Nishita D, Nöthen MM, Nurnberger J, Partonen T, Pergadia ML, Reynolds M, Ridinger M, Rose RJ, Rouvinen-Lagerström N, Scherbaum N, Schmäl C, Soyka M, Stallings MC, Steffens M, Treutlein J, Tsuang M, Wall TL, Wodarz N, Yuferov V, Zill P, Bergen AW, Chen J, Cinciripini PM, Edenberg HJ, Ehringer MA, Ferrell RE, Gelernter J, Goldman D, Hewitt JK, Hopfer CJ, Iacono WG, Kaprio J, Kreek MJ, Kremensky IM, Madden PA, McGue M, Munafò MR, Philibert RA, Rietschel M, Roy A, Rujescu D, Saarikoski ST, Swan GE, Todorov AA, Vanyukov MM, Weiss RB, Bierut LJ, Saccone NL (2016). Association of the OPRM1 variant rs1799971 (A118G) with non-specific liability to substance dependence in a collaborative de novo meta-analysis of European-ancestry cohorts. Behav Genet 2016 46:151-169. PMCID: PMC4752855.

Ramnarine S, Zhang J, Chen LS, Culverhouse R, Duan W, Hancock DB, Hartz SM, Johnson EO, Olfson E, Schwantes-An TH, Saccone NL (2015). When Does Choice of Accuracy Measure Alter Imputation Accuracy Assessments? PLoS One 10(10):e0137601. PMCID: PMC4601794.

Schwantes-An T-H, Culverhouse RC, Duan W, Ramnarine S, Rice JP, Saccone NL (2013). Interpreting joint SNP analysis results: when are two distinct signals really two distinct signals? Genet Epidemiol 2013: 37:301-309. PMCID: PMC3743534.

Schlosberg CE, Schwantes-An T-H, Duan W, Saccone NL (2011). Application of Bayesian network structure learning to identify causal variant SNPs from resequencing data. BMC Proceedings: (Proceedings of Genetic Analysis Workshop 17) 5: S109. PMCID: PMC3287832.

Saccone NL, Culverhouse RC, Schwantes-An TH, Cannon DS, Chen X, Cichon S, Giegling I, Han S, Han Y, Keskitalo-Vuokko K, Kong X, Landi MT, Ma JZ, Short SE, Stephens SH, Stevens VL, Sun L, Wang Y, Wenzlaff AS, Aggen SH, Breslau N, Broderick P, Chatterjee N, Chen J, Heath AC, Heliövaara M, Hoft NR, Hunter DJ, Jensen MK, Martin NG, Montgomery GW, Niu T, Payne TJ, Peltonen L, Pergadia ML, Rice JP, Sherva R, Spitz MR, Sun J, Wang JC, Weiss RB, Wheeler W, Witt SH, Yang BZ, Caporaso NE, Ehringer MA, Eisen T, Gapstur SM, Gelernter J, Houlston R, Kaprio J, Kendler KS, Kraft P, Leppert MF, Li MD, Madden PA, Nöthen MM, Pillai S, Rietschel M, Rujescu D, Schwartz A, Amos CI, Bierut LJ (2010). Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD. PloS Genetics 6(8): e1001053. PMCID: PMC2916847.

Saccone NL, Saccone SF, Goate AM, Grucza RA, Hinrichs AL, Rice JP, Bierut LJ (2008). In search of causal variants: refining disease association signals using cross-population contrasts. BMC Genetics 9: 58. PMCID: PMC2556340.

Last Updated: 7/24/2017 10:24:46 AM

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