Joseph C. Corbo, M.D., Ph.D.

Associate Professor
Pathology and Immunology
Genetics

Molecular Genetics and Genomics Program
Neurosciences Program
Developmental, Regenerative and Stem Cell Biology Program
Computational and Systems Biology Program

  • 314-362-6254

  • 314-362-7787

  • 314-362-4096

  • 8118

  • 3720 West Building

  • jcorbo@wustl.edu

  • https://corbolab.wustl.edu/

  • neurobiology, genomics, transcriptional networks, systems biology, photoreceptors, brain, neuropsychiatric disease, disease, cis-regulation

  • (1) transcriptional networks in the retina; (2) the mechanistic basis of color vision; (3) the cis-regulatory basis of human uniqueness and neuropsychiatric disease

Research Abstract:

In the Corbo lab, we work at the interface of neurobiology and genomics to understand the mysteries of the brain and retina. Our research has three major goals: (1) To elucidate the cis-regulatory architecture of the retina and to use this knowledge to treat blindness; (2) to understand the molecular and genetic basis of color vision, focusing on how animals both see and produce colors; and (3) to decipher the role of cis-regulatory variation in human cognition and neuropsychiatric disease. We address these problems using a wide range of techniques from the fields of genomics and neuroscience. In addition, we work with a wide range of model organisms including fish, birds, mice, and human retinal and cerebral organoids. We encourage you to visit our lab website to learn more: https://corbolab.wustl.edu/

Selected Publications:

Toomey, M.B. et al. (2016) “Complementary shifts in photoreceptor spectral tuning unlock the full adaptive potential of ultraviolet vision in birds”, eLife 5: e15675.

Lopes, R.J. et al. (2016) “Genetic basis for red coloration in birds”, Current Biology 26: 1427-34.

Shen S.Q. et al. (2016) “Massively parallel cis-regulatory analysis in the mammalian central nervous system” Genome Research 26: 238-55.

Enright, J.M. et al. (2015) “Cyp27c1 red-shifts the spectral sensitivity of photoreceptors by converting vitamin A1 into A2”, Current Biology 25: 3048-57.

White, M.A. et al. (2013) "Massively parallel in vivo enhancer assay reveals that highly local features determine the cis-regulatory function of ChIP-seq peaks", Proc Natl Acad Sci U S A. 110:11952-7.

Montana, C.L. et al. (2013) "Reprogramming of adult rod photoreceptors prevents retinal degeneration", Proc Natl Acad Sci U S A, 110: 1732-7.

Özgül, R.K. et al. (2011) "Exome sequencing and cis-regulatory mapping identify mutations in MAK, a gene encoding a regulator of ciliary length, as a cause of retinitis pigmentosa", Am. J. Hum. Genet., 89: 253-264.

Corbo, J.C. et al. (2010) "CRX ChIP-seq reveals the cis-regulatory architecture of mouse photoreceptors", Genome Res. 20:1512-25.

Last Updated: 8/24/2016 9:39:21 AM

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