Joseph C. Corbo, M.D., Ph.D.
Pathology and Immunology
Molecular Genetics and Genomics Program
Developmental, Regenerative and Stem Cell Biology Program
Computational and Systems Biology Program
3720 West Building
neurobiology, genomics, transcriptional networks, systems biology, photoreceptors, brain, neuropsychiatric disease, disease, cis-regulation
(1) transcriptional networks in the retina; (2) the mechanistic basis of color vision; (3) the cis-regulatory basis of human uniqueness and neuropsychiatric disease
In the Corbo lab, we work at the interface of neurobiology and genomics to understand the mysteries of the brain and retina. Our research has three major goals: (1) To elucidate the cis-regulatory architecture of the retina and to use this knowledge to treat blindness; (2) to understand the molecular and genetic basis of color vision, focusing on how animals both see and produce colors; and (3) to decipher the role of cis-regulatory variation in human cognition and neuropsychiatric disease. We address these problems using a wide range of techniques from the fields of genomics and neuroscience. In addition, we work with a wide range of model organisms including fish, birds, mice, and human retinal and cerebral organoids. We encourage you to visit our lab website to learn more: https://corbolab.wustl.edu/
Toomey, M.B. et al. (2016) “Complementary shifts in photoreceptor spectral tuning unlock the full adaptive potential of ultraviolet vision in birds”, eLife 5: e15675.
Lopes, R.J. et al. (2016) “Genetic basis for red coloration in birds”, Current Biology 26: 1427-34.
Shen S.Q. et al. (2016) “Massively parallel cis-regulatory analysis in the mammalian central nervous system” Genome Research 26: 238-55.
Enright, J.M. et al. (2015) “Cyp27c1 red-shifts the spectral sensitivity of photoreceptors by converting vitamin A1 into A2”, Current Biology 25: 3048-57.
White, M.A. et al. (2013) "Massively parallel in vivo enhancer assay reveals that highly local features determine the cis-regulatory function of ChIP-seq peaks", Proc Natl Acad Sci U S A. 110:11952-7.
Montana, C.L. et al. (2013) "Reprogramming of adult rod photoreceptors prevents retinal degeneration", Proc Natl Acad Sci U S A, 110: 1732-7.
Özgül, R.K. et al. (2011) "Exome sequencing and cis-regulatory mapping identify mutations in MAK, a gene encoding a regulator of ciliary length, as a cause of retinitis pigmentosa", Am. J. Hum. Genet., 89: 253-264.
Corbo, J.C. et al. (2010) "CRX ChIP-seq reveals the cis-regulatory architecture of mouse photoreceptors", Genome Res. 20:1512-25.
Last Updated: 8/24/2016 9:39:21 AM