Rajendra S. Apte, M.D., Ph.D.
Ophthalmology and Visual Sciences
Developmental, Regenerative and Stem Cell Biology Program
aging, Angiogenesis, macular degeneration, diabetes, innate immunity, macrophage, retinal degeneration, vascular biology
Innate immunity and immune effector mechanisms in the retina; oxidative stress and cell death; models of developmental angiogenesis and neovascularization; inflammation and photoreceptor survival; macular degeneration
· Investigating the role of the innate immune system in regulating angiogenesis.
· Using tissue specific deletion of soluble and membrane expressed molecular activators of macrophage function in order to define the role of these cells in regulating developmental and post-developmental angiogenesis.
· Using cell-specific deletion of genes involved in response to oxidative stress and autophagy in order to evaluate the function of the retinal pigment epithelium (RPE) and to examine the pathobiology of RPE cell death and its association with disease progression.
· To investigate the mechanisms that promote ischemia induced retinopathy during development.
· To investigate the mechanisms underlying photoceptor cell death in models of retinal disease.
· To study the role of lipids in regulating inflammation during the aging of the immune system.
· Gene expression analysis of the macrophage transcriptome and the effects of aging.
Khan AA, Dace DS, Ryazanov A, Kelly J, Apte RS. Resveratrol regulates pathologic angiogenesis by a eukaryotic elongation factor-2 kinase regulated pathway. Am J Pathol 2010 177: 481-492.
Dace DS, Khan AA, Stark JL, Kelly J, Cross AH, Apte RS. Interleukin-10 over expression promotes Fas-Ligand-Dependent chronic macrophage-mediated demyelinating polyneuropathy. Plos One 2009 4(9): 1-11.
Dace D, Khan AA, Kelly J, Apte RS. Interleukin-10 promotes pathologic developmental angiogenesis by regulating macrophage responsiveness to hypoxia. PloS One 2008 3: 3381.
Kelly J, Khan AA, Yin J, Ferguson TA, Apte RS. Senescence regulates macrophage polarization and angiogenic fate at sites of tissue injury. J Clin Invest 2007 117: 3421-3426.
Apte RS, Richter J, Herndon J, Ferguson TA. Macrophages inhibit choroidal neovascularization in age-related macular degeneration. PLoS Med 2006 3: 1371-1381.
Last Updated: 8/3/2011 1:13:08 PM