Brian N. Finck, Ph.D.

Associate Professor
Internal Medicine
Geriatrics and Nutritional Sciences

Molecular Cell Biology Program

  • 314-362-8963

  • 314-362-8230

  • 8031

  • 2711c West Building

  • bfinck@dom.wustl.edu

  • diabetes, fatty acid, insulin, cardiovascular disease, fatty liver disease, mitochondria

  • Identify novel target pathways for therapeutic treatment of obesity-related diseases including diabetes, cardiovascular disease, and fatty liver disease

Research Abstract:

My laboratory in the Division of Geriatrics and Nutritional Sciences at Washington University is focused on many aspects of lipid and glucose metabolism in insulin sensitive tissues, with special interest in the liver, and on understanding how these processes become deranged in obesity. In the course of these studies, we have become experts in a variety of areas of metabolism, including transcriptional regulation, lipid biochemistry, mitochondrial function and metabolism, and characterizing the metabolic status of mouse models. Current research projects in the lab are focused on enzymes that are involved in complex lipid synthesis as well as several projects on basic aspects of mitochondrial metabolism. We believe that these research efforts will provide important information about the regulation of basic aspects of intermediary metabolism and their impact on systemic homeostasis. The long term goal of these studies is to identify new sites for pharmaceutical intervention with the goal of targeting obesity-related metabolic disease.

Selected Publications:

1) McCommis KM, Hodges WT, Bricker D, Wisidagama DR, Remedi MS, Thummel C, and Finck BN. 2016. An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion. Mol. Metab. 5:602-614.

2) McCommis KS, Chen Z, Fu X, McDonald WG, Colca JR, Kletzien RF, Burgess SC, and Finck BN. 2015. Loss of mitochondrial pyruvate carrier 2 in liver leads to defects in gluconeogenesis and compensation via pyruvate-alanine cycling. Cell Metabolism. 22:682-694.

3) Vigueira PA, McCommis KS, Schweitzer GG, Remedi MS, Chambers KT, Fu X, McDonald WC, Cole S, Colca JR, Kletzien RF, Burgess SC, and Finck BN. 2014. Mitochondrial pyruvate carrier 2 hypomorphism in mice leads to defects in glucose-stimulated insulin secretion. Cell Reports. 7:2042-2053.

4) Hall AM, Soufi N, Chambers KT, Chen Z, Schweitzer GG, McCommis KS, Erion DM, Graham MJ, Su X, and Finck BN. 2014. Abrogating monoacylglycerol acyltransferase activity in liver improves glucose tolerance and hepatic insulin signaling in obese mice. Diabetes. 63:2284-2296.

5) Chambers KT, Chen Z, Lai L, Leone TC, Towle HC, Kralli A, Crawford PA, and Finck BN. 2013. PGC-1 and ChREBP partner to cooperatively regulate hepatic lipogenesis in a glucose concentration-dependent manner. Mol. Metab. 2:194-204.

6) Mitra MS, Chen Z, Ren H, Harris TE, Chambers KT, Hall AM, Nadra K, Klein S, Chrast R, Su X, Morris AJ, and Finck BN. 2013. Mice with an adipocyte separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulation. Proc. Natl. Acad. Sci. USA. 110:642-647.

7) Chen Z, Vigueira PA, Chambers KT, Hall AM, Mitra MS, McDonald W, Colca J, Kletzien RF, and Finck BN. 2012. Hepatic insulin resistance and metabolic derangements in obese mice are ameliorated by a novel thiazolidinedione via PPAR-independent effects. J. Biol. Chem. 287:23537-23548.

8) Peterson TR, Sengupta SS, Harris TE, Laplante M, Yesilaltay A, Madden K, Carpenter AE, Finck BN, and Sabatini DM. 2011. mTORC1 regulates lipin 1 nuclear localization to control lamin A structure and the SREBP pathway. Cell. 146: 408-420.

9) Croce MA, Eagon CJ, LaRiviere LL, Korenblat KM, Klein S, and Finck BN. 2007. Hepatic lipin 1 expression is diminished in insulin-resistant obese subjects and is reactivated by marked weight loss. Diabetes. 56: 2395-2399.

10) Finck BN, Gropler MC, Chen Z, Leone TC, Croce MA, Harris TE, Lawrence JC, and Kelly DP. 2006. Lipin 1 is an inducible amplifier of the hepatic PGC-1/PPAR regulatory pathway. Cell Metab. 4: 199-210.

Last Updated: 8/24/2016 3:07:46 PM

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