Guy M. Genin, Ph.D.

Professor
Mechanical Engineering & Materials Science
Neurological Surgery

Biochemistry, Biophysics, and Structural Biology Program
Developmental, Regenerative and Stem Cell Biology Program
Plant and Microbial Biosciences Program

  • 314-973-4228

  • 314-934-4014

  • 1099

  • Green Hall 3rd Floor

  • GENIN@WUSTL.EDU

  • mechanics, physics, interfaces, adhesion, mechanobiology, strain mapping, viscoelasticity

  • Interfaces and adhesions in physiology and nature

Research Abstract:

Interfaces and adhesions between materials present some of the greatest engineering challenges in nature, medicine, and structural design. My group studies how connections between dissimilar materials occur in nature, and applies this knowledge to propose and develop treatments and interventions. My group’s current thrust areas include adhesion of tendon to bone, interfaces within the heart in cardiomyopathy, and adaptive interfacial structures in plants. In each case, experimental and computational structural mechanics techniques and tools are at the core of our cross-disciplinary approaches.

Selected Publications:

Teresa M. Spencer, Ryan Blumenstein, Kenneth M. Pryse, Sheng-Lin Lee, David Glaubke, Brian E. Carlson, Elliot L. Elson, and Guy M. Genin. Fibroblasts Slow Conduction Velocity in a Reconstituted Tissue Model of Fibrotic Cardiomyopathy. ACS Biomaterials Science and Engineering, 2016.

Bo Cheng, Min Lin, Yuhui Li, Guoyou Huang, Guy M. Genin, Vikram S. Deshpande, Tianjian Lu, Feng Xu. An Integrated Stochastic Model of Matrix Stiffness-Dependent Filopodial Dynamics. Biophysical Journal, 2016.

Thomas E. Yankeelov, Gary An, Oliver Saut, Georg Luebeck, Aleksander S. Popel, Benjamin Ribba, Paolo Vicini, Xiaobo Zhou, Kaiming Ye, Guy M. Genin. Multi-scale Modeling in Clinical Oncology: Opportunities and Barriers to Success. Annals of Biomedical Engineering, 2016 44(9): 2626-2641.

Y. Feng, R. J. Okamoto, G. M. Genin, P. V. Bayly. Analysis of large deformations in a transversely isotropic material with two anisotropic invariants. To appear in Journal of the Mechanical Behavior of Biomedical Materials, 2016.

Markus J. Buehler* and Guy M. Genin.* Integrated multiscale biomaterials experiment and modeling: a perspective. J. Roy Soc. Interface Focus, 2016 6(1): 20150098.

Fatemeh Saadat, Alix C. Deymier-Black, Victor Birman, Stavros Thomopoulos, Guy M. Genin. The concentration of stress at the rotator cuff tendon-to-bone insertion site is conserved across species. Journal of the Mechanical Behavior of Biomedical Materials 62, pp.24-32, 2016.

Behzad Babaei, Ali Davarian, Sheng-Lin Lee, Kenneth M. Pryse, William B. McConnaughey, Elliot L. Elson,* Guy M. Genin.* Viscoelastic remodeling of collagen by human dermal fibroblasts. Acta Biomaterialia 37 (2016): 28-37.

Alix C. Deymier, Lester J. Smith, John J. Boyle, Zhen Li, Stephen W. Linderman, Jill D. Pasteris, Younan Xia, Guy M. Genin, Stavros Thomopoulos. Functionally Graded Collagen Scaffolds. J. Roy Soc. Interface Focus, 2016 6(1):20150070.

Li Hong Zhou, Shao Bao Liu, Peng Fei Wang, Tian Jian Lu, Feng Xu, Guy M. Genin,* Barbara G. Pickard.* The Arabidopsis Trichome is a Sensory Switch. To appear in Plant Cell & Environment, 2016.

Yuhui Li,* Guoyou Huang,* Moxiao Li, Lin Wang, Elliot L. Elson, Tian Jian Lu, Guy M. Genin,* Feng Xu.* Magnetically activated synthetic tissues and a first look at high strain cellular mechanosensitivity in three-dimensional culture. To appear in Scientific Reports, 2016.

Elliot L. Elson and Guy M. Genin. Tissue Constructs: Platforms for Basic Research and Drug Discovery. J. Roy Soc. Interface Focus 20150095, 2016.

Li, Y., Huang, G., Gao, B., Li, M., Genin, G.M., Lu, T.J. and Xu, F., 2016. Magnetically actuated cell-laden microscale hydrogels for probing strain-induced cell responses in three dimensions. NPG Asia Materials, 8(1), p.e238.

Last Updated: 10/21/2016 9:27:16 AM

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