Ting Wang, Ph.D.

Sanford C. and Karen P. Loewentheil Distinguished Professor

Computational and Systems Biology Program
Molecular Genetics and Genomics Program
Evolution, Ecology and Population Biology Program
Human and Statistical Genetics Program

  • 314-286-0865

  • 314-286-0866

  • MRB - McKinley Research Building, Room 4208

  • twang@wustl.edu

  • http://wang.wustl.edu/

  • DNA methylation, transposable elements, epigenomics, evolution, genomics, systems biology

  • Epigenome evolution and epigenetic determinants of cell fate

Research Abstract:

The big question: how does one genome encode different epigenomes, and how do different genomes encode the same epigenome?

I am fascinated by the evolution and adaption of gene regulatory networks. Research in my lab focuses on understanding genetic and epigenetic factors that determine cell fate, including cell fate in normal development and differentiation, abnormal cell fate in cancer, and how specific cell types evolve. Specifically, my lab investigates the roles of transposable elements and the roles of DNA methylation in these processes.

We develop experimental and computational technologies in parallel, obliterating the boundary between wet and dry labs.

Selected Publications:

Lee HJ, Lowdon RF, Maricque B, Zhang B, Stevens M, Li D, Johnson SL, Wang T. (2015) Developmental enhancers revealed by extensive DNA methylome maps of zebrafish early embryos. Nat Commun. 2015 Feb 20;6:6315. PMCID: PMC4339225.

Roadmap Epigenomics Consortium, Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, Kheradpour P, Zhang Z, Wang J, Ziller MJ, Amin V, Whitaker JW, Schultz MD, Ward LD, Sarkar A, Quon G, Sandstrom RS, Eaton ML, Wu YC, Pfenning AR, Wang X, Claussnitzer M, Liu Y, Coarfa C, Harris RA, Shoresh N, Epstein CB, Gjoneska E, Leung D, Xie W, Hawkins RD, Lister R, Hong C, Gascard P, Mungall AJ, Moore R, Chuah E, Tam A, Canfield TK, Hansen RS, Kaul R, Sabo PJ, Bansal MS, Carles A, Dixon JR, Farh KH, Feizi S, Karlic R, Kim AR, Kulkarni A, Li D, Lowdon R, Elliott G, Mercer TR, Neph SJ, Onuchic V, Polak P, Rajagopal N, Ray P, Sallari RC, Siebenthall KT, Sinnott-Armstrong NA, Stevens M, Thurman RE, Wu J, Zhang B, Zhou X, Beaudet AE, Boyer LA, De Jager PL, Farnham PJ, Fisher SJ, Haussler D, Jones SJ, Li W, Marra MA, McManus MT, Sunyaev S, Thomson JA, Tlsty TD, Tsai LH, Wang W, Waterland RA, Zhang MQ, Chadwick LH, Bernstein BE, Costello JF, Ecker JR, Hirst M, Meissner A, Milosavljevic A, Ren B, Stamatoyannopoulos JA, Wang T, Kellis M. (2015) Integrative analysis of 111 reference human epigenomes. Nature. 2015 Feb 19;518(7539):317-30.

Zhou X, Li D, Zhang B, Lowdon RF, Rockweiler NB, Sears RL, Madden PA, Smirnov I, Costello JF, Wang T. (2015) Epigenomic annotation of genetic variants using the Roadmap Epigenome Browser. Nat Biotechnol. 2015 Feb 18.

Lowdon RF, Zhang B, Bilenky M, Mauro T, Li D, Gascard P, Sigaroudinia M, Farnham PJ, Bastian BC, Tlsty TD, Marra MA, Hirst M, Costello JF, Wang T, Cheng JB (2014). Regulatory network decoded from epigenomes of surface ectoderm-derived cell types. Nat Commun. 2014 Nov 25;5:5442.

Sundaram V, Cheng Y, Ma Z, Li D, Xing X, Edge P, Snyder M, Wang T. (2014) Widespread contribution of transposable elements to the innovation of gene regulatory networks. Genome Res. 2014 Dec;24(12):1963-76. PMCID: PMC4248313.

Li D, Zhang B, Xing X, Wang T. (2014) Combining MeDIP-seq and MRE-seq to investigate genome-wide CpG methylation. Methods. 2014 Nov 6. pii: S1046-2023(14)00359-4. doi: 10.1016/j.ymeth.2014.10.032. PMCID: PMC4300244.

Zhang B, Xing X, Li J, Lowdon RF, Zhou Y, Lin N, Zhang BX, Sundaram V, Chiappinelli KB, Hagemann IS, Mutch DG, Goodfellow PJ, Wang T. (2014) Comparative DNA methylome analysis of endometrial carcinoma reveals complex and distinct deregulation of cancer promoters and enhancers. BMC Genomics 2014 Oct 6;15(1):868. PMCID: PMC4198682.

Stevens M, Cheng JB, Li D, Xie M, Hong C, Maire CL, Ligon KL, Hirst M, Marra MA, Costello JF, Wang T. (2013) Estimating absolute methylation levels at single CpG resolution from methylation enrichment and restriction enzyme sequencing methods. Genome Res. 2013 Jun 26. [Epub ahead of print]

Zhang B, Zhou Y, Lin N, Lowdon RF, Hong C, Nagarajan RP, Cheng JB, Li D, Stevens M, Lee HJ, Xing X, Zhou J, Sundaram V, Elliott G, Gu J, Gascard P, Sigaroudinia M, Tlsty TD, Kadlecek T, Weiss A, O`Geen H, Farnham PJ, Maire CL, Ligon KL, Madden PA, Tam A, Moore R, Hirst M, Marra MA, Zhang B, Costello JF, Wang T. (2013) Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm. Genome Res. 2013 Jun 26. [Epub ahead of print]

Xie M, Hong C, Zhang B, Lowdon RF, Xing X, Li D, Zhou X, Lee HJ, Maire CL, Ligon KL, Gascard P, Sigaroudinia M, Tlsty TD, Kadlecek T, Weiss A, O`Geen H, Farnham PJ, Madden PA, Mungall AJ, Tam A, Kamoh B, Cho S, Moore R, Hirst M, Marra MA, Costello JF, and Wang T. (2013) DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape. Nat Genet. 2013 May 26;45(7):836-841.

Zhou X, Lowdon RF, Li D, Lawson HA, Madden PA, Costello JF, Wang T. (2013) Exploring long-range genome interactions using the WashU Epigenome Browser. Nat Methods. 2013 May;10(5):375-6.

Zhou X, Maricque B, Xie M, Li D, Sundaram V, Martin E, Koebee B, Nielsen C, Hirst M, Farnham P, Kuhn R, Zhu J, Smirnov I, Kent J, Haussler D, Madden P, Costello JF, Wang T. (2011) The human epigenome browser at Washington University. Nat Methods 2011, 8(12):989-990

Maunakea AK, Nagarajan RP, Bilenky M, Ballinger TJ, D`Souza C, Fouse SD, Johnson BE, Hong C, Nielson C, Zhao Y, Turecki G, Delaney A, Varhol R, Thiessen N, Shchors K, Heine VM, Rowitch DH, Xing X, Fiore C, Schillebeeckx M, Jones SSJ, Haussler D, Marra MA, Hirst M, Wang T, Costello JF. (2010) Conserved role of intragenic DNA methylation in regulating alternative promoters. Nature 2010 466(7303): 253-257.

Last Updated: 9/1/2015 11:12:09 AM

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