Joseph D. Dougherty, Ph.D.
Molecular Genetics and Genomics Program
Computational and Systems Biology Program
Human and Statistical Genetics Program
autism, gene expression profiling, genetics, genomics, mouse models, neurobiology
Human Psychiatric Genetics, Mouse Models, Cell Type Specific Gene Expression Profiling.
Our laboratory utilizes a variety of techniques spanning from human molecular genetics and informatics to mouse behavioral neuroscience and neuroanatomy. We develop and employ mouse models of psychiatric disorder, particularly those that mimic genetic variations we’ve identified from human patient populations, with the goal of trying to understand the cellular and molecular underpinnings of these disorders. We are particularly focused on the neurodevelopmental disorder of autism.
Dougherty, J.D., Zhang, J., Feng, H., Gong, S., and Heintz, N. (2012). Mouse transgenesis in a single locus with independent regulation for multiple fluorophores. PLoS One 7, e40511.
Tien, A.C., Tsai, H.H., Molofsky, A.V., McMahon, M., Foo, L.C., Kaul, A., Dougherty, J.D., Heintz, N., Gutmann, D.H., Barres, B.A., et al. (2012). Regulated temporal-spatial astrocyte precursor cell proliferation involves BRAF signalling in mammalian spinal cord. Development 139, 2477-2487.
Fomchenko, E.I., Dougherty, J.D., Helmy, K.Y., Katz, A.M., Pietras, A., Brennan, C. Husel, J.T., Milosevic, A., and Holland, E.C. (2011). Recruited cells can become transformed and overtake PDGF-induced murine gliomas in vivo during tumor progression. Plos One, 6(7): e20605. PMID: 21754979
Dougherty JD, Schmidt EF, Nakajima M, Heintz N. Analytical approaches to RNA profiling data for the identification of genes enriched in specific cells. Nuc Acids Research 2010 38(13):4218-30.
Doyle JP*, Dougherty JD*, Heiman M, Schmidt EF, Stevens TR, Ma G, Bupp S, Shrestha P, Shah RD, Doughty ML, Gong S, Greengard P, Heintz N. Application of a translational profiling approach for the comparative analysis of CNS cell types. Cell 2008 135: 749-62.
Nakano I*, Dougherty JD*, Kim K, Klement I, Geschwind DH, and Kornblum HI. Phosphoserine phosphatase is expressed in the neural stem cell niche and regulates neural stem and progenitor cell proliferation. Stem Cells 2007 25:1975-1984.
Groszer M, Erickson R, Scripture-Adams DD, Dougherty JD, Le Belle J, Zack JA, Geschwind DH, Liu X, Kornblum HI, and Wu H. PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry. Proc Natl Acad SciU S A 2006 103: 111-116.
Dougherty JD, Garcia AD, Nakano I, Livingstone M, Norris B, Polakiewicz R, Wexler EM, Sofroniew MV, Kornblum HI, and Geschwind DH. PBK/TOPK, a proliferating neural progenitorspecific mitogen-activated protein kinase kinase. J Neurosci 2005 25: 10773-10785.
Last Updated: 8/22/2012 4:38:28 PM