David Queller, Ph.D.

Spencer T. Olin Professor

Evolution, Ecology and Population Biology Program
Developmental, Regenerative and Stem Cell Biology Program
Molecular Genetics and Genomics Program

  • 314-935-3528

  • 1137

  • 308 Wilson

  • Queller@wustl.edu

  • http://strassmannandquellerlab.wordpress.com/

  • social interactions, evolution, microbiology, social amoebae, kin selection, moleuclar evolution, multicellularity, development, genomics

  • The evolution of sociality, cooperation, and cheating in a eukaryotic microbe, using experimental evolution, genomics, and other approaches

Research Abstract:

Evolution usually favors "selfish" individuals that outcompete others, but it has nevertheless forged highly cooperative entities like social insect colonies, multicellular organisms, and the eukaryotic cell. I am interested in how cooperation and altruism evolve, with questions ranging from the genetic and molecular details of cooperation in social amoebas up to the nature of organisms. In empirical studies with Joan Strassmann, we have largely shifted from work on social insects to social amoebas. This gives us the opportunity to do experimental evolution studies and to study cooperation, cheating, and kin recognition at the genetic, molecular and genomic levels. On the theoretical side, I explore this evolution of cooperation with models using population genetics, inclusive fitness, or game theory. Future directions may include the evolution of multicellularity and genomic imprinting in social insects.

Selected Publications:

Queller, D.C. 2014. Joint phenotypes, evolutionary conflict, and the fundamental theorem of natural selection. Phil. Trans. Roy. Soc. B in press.

Strassmann, J.E. and Queller, D.C. 2014. Privatization and property in biology. Animal Behaviour in press.

Patten, M.M., Ross, L., Curley, J.P., Queller, D.C., Bonduriansky, R., and Wolf, J.B. 2014. The evolution of genomic imprinting: theories, predictions, and empirical tests. Heredity in press.

Stallforth, P, Brock, D.A., Cantley, A.M., Tian, X., Queller, D.C., Strassmann, J.E., and Clardy, J. 2013. A bacterial symbiont is converted from an inedible producer of beneficial molecules into food by a single mutation in the gacA gene. Proc. Natl. Acad. Sci. USA 100:14528-14533.

Hall, D. W., Fox, S., Kuzdzal,-Fick, J., Strassmann, J. E., Queller, D. C. 2013. The rate and effects of spontaneous mutation on fitness traits in the social amoeba Dictyostelium discoideum. G3: Genes, Genomes, Genetics. 3:1115-1127.

Tian, X., Strassmann, J.E. and Queller, D.C. 2013. Dictyostelium development shows a novel pattern of evolutionary conservation. Molecular Biology and Evolution 30: 977-984.

Kuzdzal-Fick, J.A., Fox, S.A., Strassmann, J.E. & Queller, D. C. 2011.
High relatedness is necessary and sufficient to maintain multicellularity in Dictyostelium. Science 334: 1548-1551.

Queller, D. C. 2011. Expanded social fitness and Hamilton`s rule for kin, kith, and kind. Proc. Natl. Acad. Sci. USA 108: 10792-10799.

Strassmann, J. E., Gilbert, O. M., & Queller, D. C. 2011. Kin discrimination and cooperation in microbes. Annual Review of Microbiology 65:349-367.

Last Updated: 3/21/2014 9:22:55 AM

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