Gwen Randolph, Ph.D.

Professor
Pathology and Immunology
Immunobiology
Internal Medicine

Immunology Program
Molecular Microbiology and Microbial Pathogenesis Program

  • 314-286-2345

  • 314 286-2361

  • 314 286-2362

  • 8118

  • BJCIH 8th floor, room 8307

  • grandolph@path.wustl.edu

  • https://pathology.wustl.edu/directory/gwendalyn-randolph-phd/

  • monocytes, dendritic cells, lymphatic vessels, lymph nodes, in vivo

  • Our research integrates the study of monocytes, monocyte-derived cells, and dendritic cells with vascular and lymphatic vessel biology

Research Abstract:

My laboratory’s research integrates the study of monocytes, monocyte-derived cells, and dendritic cells with vascular and lymphatic vessel biology. We have pioneered assays to study migration of these immune cells to lymph nodes in various tissues. We have also developed assays to study the differentiation and migration of human monocytes and dendritic cells across vascular and lymphatic barriers.

Current studies examine the recruitment of monocytes to sites of acute and chronic inflammation (e.g.,
atherosclerotic plaques) and then follow the fate of these cells thereafter. Through our studies on the migration of monocyte-derived dendritic cells and other dendritic cells through lymphatic vessels, we have also taken a keen interest in the functional properties of lymphatic vessels and the adipose tissue that surrounds them. We are thus branching out to explore crosstalk between immune cells and lymphatics and how these interactions might affect lymphatic function, immune and inflammatory responses, and adipose tissue.

Selected Publications:


K Kim, JW Williams, Y Wang, S Ivanov, S Gilfillan, M Colonna, HW Virgin, EL Gautier, GJ Randolph. 2016. MHC II+ resident peritoneal and pleural macrophages rely on microbiome and IRF4 for development from circulating monocytes, J. Exp. Med., 213(10):1951-9

GJ Randolph, S Bala, JF Rahier, MW Johnson, PL Wang, I Nalbantoglu, L Dubuquoy, A Chau, B Pariente, A Kartheuser, BH Zinselmeyer, JF Colombel. 2016. Lymphoid aggregates remodel lymphatic collecting vessels that serve mesenteric lymph nodes in Crohn`s disease. Amer J Pathol., 186:3066-3073. [article highlighted by the Society of Mucosal Immunology as one of 8 Featured Papers for 2016; http://www.socmucimm.org/publications/related-papers/]

Ivanov S, Scallan JP, Kim KW, Werth K, Johnson MW, Saunders BT, Wang PL, Kuan EL, Straub AC, Ouhachi M, Weinstein EG, Williams JW, Briseno C, Colonna M, Isakson BE, Gautier EL, Foerster R, Davis MJ, Zinselmeyer BH, Randolph GJ. 2016. CCR7 and IRF4-dependent dendritic cells regulate lymphatic collecting vessel permeability. J. Clin. Invest., 126: 1581-91. PMID: 2699610

Kuan EL, Ivanov S, Bridenbaugh EA, Victora G, Wang W, Childs EW, Platt AM, Jakubzick CV, Mason RJ, Gashev AA, Nussenzweig M, Swartz MA, Dustin ML, Zaweija DC, Randolph GJ. 2015. Collecting lymphatic vessel permeability facilitates adipose tissue inflammation and distribution of antigen to lymph node-homing adipose tissue dendritic cells. J. Immunol., Jun 1;194(11):5200-10. PMID: 2699610 [cover feature]

Gautier EL, Ivanov S, Williams JW, Huang SC, Marcelin G, Fairfax K, Wang PL, Francis JS, Leone P, Wilson DB, Artyomov MN, Pearce EJ, and Randolph GJ. Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival. J Exp Med 2014;211(8):1525-1531. PMCID: PMC4113942


Jakubzick, C., Gautier,E. L., Gibbings,E. L., Sojka,D., Schlitzer,D. K., Ivanov, S., T. E. Johnson, Q. Duan, S. Bala, T. Condon, N. Van Rooijen, J. R. Grainger, Y. Belkaid, A. Ma’ayan, W. M. Yokoyama, F. Ginhoux, P. Henson, G. J. Randolph. 2013. Minimal differentiation of classical monocytes as they survey steady state tissues and transport antigens to lymph nodes. Immunity.

Gautier, E. L., Ivanov, S., Lesnik, P. Randolph, G. J. Local apoptosis mediates clearance of macrophages from resolving inflammation in mice. 2013. BLOOD.

C. Martel, W. Li, B. Fulp, A. M. Platt, E. L. Gautier, M.Westerterp, R. Bittman, A. R. Tall, S. H. Chen, M. J. Thomas, D. Kreisel, M. A. Swartz, M. G. Sorci-Thomas, G. J. Randolph. 2013. Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice. J. Clin. Invest., 123:1571-1579. PMCID: 3613904

A. M. Platt, J. M. Rutkowski, C. Martel, E.L. Kuan, S. Ivanov, M.A. Swartz, G.J. Randolph. 2013. Normal dendritic cell mobilization to lymph nodes under conditions of severe lymphatic hypoplasia. J. Immunol, 190:4608-4620. PMCID: 3634097.

E. L. Gautier, T. Shay, J. Miller, M. Greter, C. Jakubzick, J. Helft, A. Chow, K. G. Elpek, S. Gordonov, A. R. Mazloom, W-J Chua, T. H. Hansen, A. Ma’ayan, S. J. Turley, M. Merad, G. J Randolph. 2012. Gene expression profiles and transcriptional regulatory pathways underlying murine tissue macrophage identity and diversity. Nat. Immunol. 13:118-1128. PMCID: 3558276.




Last Updated: 9/5/2017 10:12:06 PM

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