Gwen Randolph, Ph.D.

Professor
Pathology and Immunology
Immunobiology
Internal Medicine

Immunology Program
Molecular Microbiology and Microbial Pathogenesis Program

  • 314-286-2345

  • 314 286-2361

  • 314 286-2362

  • 8118

  • BJCIH 8th floor, room 8307

  • grandolph@path.wustl.edu

  • monocytes, dendritic cells, lymphatic vessels, lymph nodes, in vivo

  • Our research integrates the study of monocytes, monocyte-derived cells, and dendritic cells with vascular and lymphatic vessel biology

Research Abstract:

My laboratory’s research integrates the study of monocytes, monocyte-derived cells, and dendritic cells with vascular and lymphatic vessel biology. We have pioneered assays to study migration of these immune cells to lymph nodes in various tissues. We have also developed assays to study the differentiation and migration of human monocytes and dendritic cells across vascular and lymphatic barriers.

Current studies examine the recruitment of monocytes to sites of acute and chronic inflammation (e.g.,
atherosclerotic plaques) and then follow the fate of these cells thereafter. Through our studies on the migration of monocyte-derived dendritic cells and other dendritic cells through lymphatic vessels, we have also taken a keen interest in the functional properties of lymphatic vessels and the adipose tissue that surrounds them. We are thus branching out to explore crosstalk between immune cells and lymphatics and how these interactions might affect lymphatic function, immune and inflammatory responses, and adipose tissue.

Selected Publications:

Jakubzick, C., Gautier,E. L., Gibbings,E. L., Sojka,D., Schlitzer,D. K., Ivanov, S., T. E. Johnson, Q. Duan, S. Bala, T. Condon, N. Van Rooijen, J. R. Grainger, Y. Belkaid, A. Ma’ayan, W. M. Yokoyama, F. Ginhoux, P. Henson, G. J. Randolph. 2013. Minimal differentiation of classical monocytes as they survey steady state tissues and transport antigens to lymph nodes. Immunity, In press.

Gautier, E. L., Ivanov, S., Lesnik, P. Randolph, G. J. Local apoptosis mediates clearance of macrophages from resolving inflammation in mice. BLOOD, in press.

C. Martel, W. Li, B. Fulp, A. M. Platt, E. L. Gautier, M.Westerterp, R. Bittman, A. R. Tall, S. H. Chen, M. J. Thomas, D. Kreisel, M. A. Swartz, M. G. Sorci-Thomas, G. J. Randolph. 2013. Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice. J. Clin. Invest., 123:1571-1579. PMCID: 3613904

A. M. Platt, J. M. Rutkowski, C. Martel, E.L. Kuan, S. Ivanov, M.A. Swartz, G.J. Randolph. 2013. Normal dendritic cell mobilization to lymph nodes under conditions of severe lymphatic hypoplasia. J. Immunol, 190:4608-4620. PMCID: 3634097.

E. L. Gautier, T. Shay, J. Miller, M. Greter, C. Jakubzick, J. Helft, A. Chow, K. G. Elpek, S. Gordonov, A. R. Mazloom, W-J Chua, T. H. Hansen, A. Ma’ayan, S. J. Turley, M. Merad, G. J Randolph. 2012. Gene expression profiles and transcriptional regulatory pathways underlying murine tissue macrophage identity and diversity. Nat. Immunol. 13:118-1128. PMCID: 3558276.

Gautier EL, Chow A, Spanbroek R, Marcelin G, Greter M, Jakubzick C, Bogunovic M, Leboeuf M, van Rooijen N, Habenicht AJ, Merad M, Randolph GJ. 2012. Systemic Analysis of PPARγ in Mouse Macrophage Populations Reveals Marked Diversity in Expression with Critical Roles in Resolution of Inflammation and Airway Immunity. J. Immunol., 189:2614-2624. PMCID: 3537497

Potteaux S, Gautier EL, Hutchison SB, van Rooijen N, Rader DJ, Thomas M, Sorci-Thomas M, Randolph GJ. Suppressed monocyte recruitment drives macrophage removal from atherosclerotic plaques of ApoE-/- mice during disease regression. J. Clin. Invest. 2011 121:2025-2036. PMID: 21505265.

Ingersoll MA, Spanbroek R, Lottaz C, Gautier EL, Frankenberger M, Hoffmann R, Lang R, Haniffa M, Collin M, Tacke F, Habenicht AJR, Ziegler-Heitbrock L, Randolph GJ. Comparison of gene expression profiles between human and mouse monocyte subsets. Blood 2010 115:e10-19.

Yvan-Charvet L, Pagler T, Gautier EL, Avagyan S, Siry RL, Han S, Welch CL, Wang N, Randolph GJ, Snoeck HW, Tall AR. ATP-binding cassette transporters and HDL suppress hematopoietic stem cell proliferation. Science 2010 328: 1689-93.

Last Updated: 8/19/2013 12:01:41 PM

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