Sergej Djuranovic, Ph.D.

Assistant Professor
Cell Biology and Physiology

Molecular Cell Biology Program
Biochemistry, Biophysics, and Structural Biology Program

  • (314)362-9706

  • (314)362-8936

  • (314)362-7463

  • 8228

  • 514 McDonnell Science Building


  • biochemistry, miRNA, RNA, Ribosome, translation, gene expression, translational control, cancer, malaria

  • Molecular mechanisms of translational control

Research Abstract:

Dr. Djuranovic`s research examines the cellular processes that are regulated by changes in RNA metabolism. The primary focus of his research are molecular mechanisms of gene expression control by miRNAs and RNA-binding proteins. Dr. Djuranovic group studies also mechanism of action as well as evolutionary conservation of RNA and protein motifs that regulate gene expression by direct interaction with protein synthesis machinery.

Selected Publications:

Cottrell KA, Chaudhari HG, Cohen BA, Djuranovic S. PTRE-seq reveals mechanism and interactions of RNA binding proteins and miRNAs. Nature Communications, 9: 301, 2018 Jan 19

Cottrell KA, Szczesny P, Djuranovic S. Translation efficiency is a determinant
of the magnitude of miRNA-mediated repression. Sci Rep. 2017 Nov 2;7(1):14884.

Arthur L. L., Chung J. J., Jankirama P., Keefer K. M., Kolotilin I., Pavlovic-Djuranovic S., Chalker D. L., Grbic V., Green R., Menassa R., True H. L., Skeath J. B. & Djuranovic S.,
Rapid generation of hypomorphic mutations. Nature Communications. 8, 14112 doi: 10.1038/ncomms14112 (2017).

Cottrell K.A., Djuranovic S., Urb-RIP - An Adaptable and Efficient Approach for Immunoprecipitation of RNAs and Associated RNAs/Proteins. 2016, PLoS One, 11(12):e0167877.

Habich M., Djuranovic S., Szczesny P., PATACSDB—the database of polyA translational attenuators in coding sequences. 2016, PeerJ Computer Science 2:e45

Daane JM, Rohner N, Konstantinidis P, Djuranovic S, Harris MP. Parallelism and Epistasis in Skeletal Evolution Identified through Use of Phylogenomic Mapping Strategies. Mol Biol Evol. 2015 Oct 8.

Arthur LL, Pavlovic-Djuranovic S, Smith-Koutmou K, Green R, Szczesny P, Djuranovic S. Translational control by lysine-encoding A-rich sequences. Science Adv. 2015 Jul;1(6).

Koutmou KS, Schuller AP, Brunelle JL, Radhakrishnan A, Djuranovic S, Green R. Ribosomes slide on lysine-encoding homopolymeric A stretches. Elife. 2015 Feb 19;4.

Hur JK, Zinchenko MK, Djuranovic S, Green R. Regulation of Argonaute slicer activity by guide RNA 3` end interactions with the N-terminal lobe. J Biol Chem. 2013 288(11):7829-40.

Djuranovic S, Nahvi A, Green R. miRNA-mediated gene silencing by translational repression followed by mRNA deadenylation and decay. Science. 2012 336(6078):237-40

Grbić M, Van Leeuwen T, Clark RM, Rombauts S, Rouz P, Grbić V, Osborne EJ, Dermauw W, Ngoc PC, Ortego F, Hernndez-Crespo P, Diaz I, Martinez M, Navajas M, Sucena , Magalhes S, Nagy L, Pace RM, Djuranović S, Smagghe G, Iga M, Christiaens O, Veenstra JA, Ewer J, Villalobos RM, Hutter JL, Hudson SD, Velez M, Yi SV, Zeng J, Pires-daSilva A, Roch F, Cazaux M, Navarro M, Zhurov V, Acevedo G, Bjelica A, Fawcett JA, Bonnet E, Martens C, Baele G, Wissler L, Sanchez-Rodriguez A, Tirry L, Blais C, Demeestere K, Henz SR, Gregory TR, Mathieu J, Verdon L, Farinelli L, Schmutz J, Lindquist E, Feyereisen R, Van de Peer Y. The genome of Tetranychus urticae reveals herbivorous pest adaptations. Nature. 2011 479(7374):487-92.

Djuranovic S, Nahvi A, Green R. A parsimonious model for gene regulation by miRNAs. Science. 2011;331(6017):550-3.

Varnay I, Truffault V, Djuranovic S, Ursinus A, Coles M, Kessler H. Optimized measurement temperature gives access to the solution structure of a 49 kDa homohexameric β-propeller. J Am Chem Soc. 2010 132(44):15692-8.

Djuranovic S, Zinchenko MK, Hur JK, Nahvi A, Brunelle JL, Rogers EJ, Green R. Allosteric regulation of Argonaute proteins by miRNAs. Nat Struct Mol Biol. 2010 Feb;17(2):144-50.

Djuranovic S, Hartmann MD, Habeck M, Ursinus A, Zwickl P, Martin J, Lupas AN, Zeth K. Structure and activity of the N-terminal substrate recognition domains in proteasomal ATPases. Mol Cell. 2009 Jun 12;34(5):580-90.

Asen I, Djuranovic S, Lupas AN, Zeth K. Crystal structure of SpoVT, the final modulator of gene expression during spore development in Bacillus subtilis. J Mol Biol. 2009 Mar 6;386(4):962-75.

Schmidt O, Schuenemann VJ, Hand NJ, Silhavy TJ, Martin J, Lupas AN, Djuranovic S. prlF and yhaV encode a new toxin-antitoxin system in Escherichia coli. J Mol Biol. 2007 Sep 28;372(4):894-905.

Last Updated: 1/19/2018 11:19:59 AM

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