Tammie L.S. Benzinger, MD, PhD


Neurosciences Program
Biomedical Informatics and Data Science Program

  • 314 362-5950

  • 314-362-1558

  • 8131

  • Neuroimaging Laboratories, Mallinckrodt Institute of Radiology, Room 2111 East Bldg.

  • benzingert@wustl.edu

  • https://sites.wustl.edu/benzinger/

  • https://twitter.com/BenzingerNeuro1

  • MRI, PET, Alzheimer’s disease, aging, imaging biomarkers for clinical trials

  • Novel neuroimaging approaches to study aging and Alzheimer's disease.

Research Abstract:

Dr. Benzinger`s research focuses on translational magnetic resonance imaging (MRI) and positron emisson tomography (PET) imaging in the study of healthy aging and Alzheimer disease (AD) and related dementias (ADRD). The lab serves as a hub for quickly moving new MR and PET techqnicues into human studies, clinical trials, and clinical practice. As part of the Knight Alzheimer Reserach Imaging Program (KARI), we have developed rich, large longitudinal imaging datasets which allow for modeling these complex human neurodegenerative diseases.

Mentorship and Commitment to Diversity Statement:
Our lab is committeed to teaching and mentoring people from a variety of personal experiences, values, and worldviews that arise from differences of culture and circumstance.

Selected Publications:

Wang Q, Chen G, Schindler SE, Christensen J, McKay NS, Liu J, Wang S, Sun Z, Hassenstab J, Su Y, Flores S, Hornbeck R, Cash L, Cruchaga C, Fagan AM, Tu Z, Morris JC, Mintun MA, Wang Y, Benzinger TLS. Baseline Microglial Activation Correlates With Brain Amyloidosis and Longitudinal Cognitive Decline in Alzheimer Disease. Neurol Neuroimmunol Neuroinflamm. 2022 May;9(3). doi: 10.1212/NXI.0000000000001152. Print 2022 May. PubMed PMID: 35260470; PubMed Central PMCID: PMC8906187.

Koenig LN, LaMontagne P, Glasser MF, Bateman R, Holtzman D, Yakushev I, Chhatwal J, Day GS, Jack C, Mummery C, Perrin RJ, Gordon BA, Morris JC, Shimony JS, Benzinger TLS. Regional age-related atrophy after screening for preclinical alzheimer disease. Neurobiol Aging. 2022 Jan;109:43-51. doi: 10.1016/j.neurobiolaging.2021.09.010. Epub 2021 Sep 15. PubMed PMID: 34655980; PubMed Central PMCID: PMC9009406.

Brier MR, Snyder AZ, Tanenbaum A, Rudick RA, Fisher E, Jones S, Shimony JS, Cross AH, Benzinger TLS, Naismith RT. Quantitative signal properties from standardized MRIs correlate with multiple sclerosis disability. Ann Clin Transl Neurol. 2021 May;8(5):1096-1109. doi: 10.1002/acn3.51354. Epub 2021 May 4. PubMed PMID: 33943045; PubMed Central PMCID: PMC8108425.

Bateman RJ, Xiong C, Benzinger TL, Fagan AM, Goate A, Fox NC, Marcus DS, Cairns NJ, Xie X, Blazey TM, Holtzman DM, Santacruz A, Buckles V, Oliver A, Moulder K, Aisen PS, Ghetti B, Klunk WE, McDade E, Martins RN, Masters CL, Mayeux R, Ringman JM, Rossor MN, Schofield PR, Sperling RA, Salloway S, Morris JC. Clinical and biomarker changes in dominantly inherited Alzheimer`s disease. N Engl J Med. 2012 Aug 30;367(9):795-804. PubMed Central PMCID: PMC3474597.

Benzinger TL*, Blazey T*, Jack CR Jr, Koeppe RA, Su Y, Xiong C, Raichle ME, Snyder AZ, Ances BM, Bateman RJ, Cairns NJ, Fagan AM, Goate A, Marcus DS, Aisen PS, Christensen JJ, Ercole L, Hornbeck RC, Farrar AM, Aldea P, Jasielec MS, Owen CJ, Xie X, Mayeux R, Brickman A, McDade E, Klunk W, Mathis CA, Ringman J, Thompson PM, Ghetti B, Saykin AJ, Sperling RA, Johnson KA, Salloway S, Correia S, Schofield PR, Masters CL, Rowe C, Villemagne VL, Martins R, Ourselin S, Rossor MN, Fox NC, Cash DM, Weiner MW, Holtzman DM, Buckles VD, Moulder K, Morris JC. Regional variability of imaging biomarkers in autosomal dominant Alzheimer`s disease. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):E4502-9. PubMed Central PMCID: PMC3839740.

Gordon B, Blazey T, Su Y, Hari-Raj A, Dincer A, Ances B, Flores S, Christensen J, McDade E, Wang G, iong C, Cairns NJ, Hassenstab J, Marcus DS, Fangan AM, Jack Jr C, Hornbeck R, Paumier K, Berman BM, Brickman A, Cash D, Chhatwal J, Correia S, Forster S, Fox NC, Graff-Radford NR, Fougere C, Levin J, Masters CL, Rosser M, Salloway S, Saykin AJ, Schofield PR, Thompson PM, Weiner M, Holtzman DM, Raichle ME, Morris JC, Bateman RJ, Benzinger TLS, Dominantly Inherited Alzheimer N. Spatial patterns of longitudinal neuroimaging biomarker change in autosomal dominant Alzheimer disease. Lancet neurology. 2018 Mar;17(3):241-250. PubMed PMID: 29397305; PMCID: PMC5816717

Complete List of Published Work in My Bibliography: https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/40199677

Last Updated: 11/7/2022 12:25:09 PM

Beta-amyloid deposition in pre-symptomatic and symptomatic carriers of Alzheimer`s disease-causing gene mutations.
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