Tammie L.S. Benzinger, MD, Ph.D
Neuroimaging Laboratories, Mallinckrodt Institute of Radiology, Room 2111, 4525 Scott Ave., St. Louis, MO 63110
MRI, PET, Alzheimer’s disease, brain tumors, aging, imaging biomarkers for clinical trials
the integration of MRI and PET using simultaneous acquisition (combined PET-MRI scanning) in both Alzheimer’s disease and brain tumor research
Dr. Benzinger`s research focuses on translating advanced neuromagnetic resonance imaging techniques from small animal research in the Department of Radiology, to translational research in the Center for Clinical Imaging Research (CCIR), and into clinical practice. In particular, her current research focuses on using directional diffusivity measurements derived from diffusion tensor imaging (DTI) to measure axonal and myelin damage in pediatric and adult demyelination, dysmyelinating diseases, in traumatic brain injury (TBI), and as a function of aging. Diseases under study in Dr. Benzinger`s laboratory include multiple sclerosis (MS), acute disseminated encephalomyelitis (ADEM), adrenoleukodystrophy, Krabbe`s disease, Pelizaeus-Merzbacher`s disease, and head trauma. In addition, Dr. Benzinger combines advanced neuromagnetic resonance techniques, such as DTI and spectroscopy, and positron emission tomography (PET) to study interactions between normal aging, Alzherimer`s disease, depression, and delirium in older adults.
Benzinger TLS, Liang H, Sun S, Cross AH, Schmidt RE, Song S. Axial and radial diffusivity as MR biomarkers of axonal and myelin injury in ex-vivo cervical spinal cord from multiple sclerosis patients. Proceedings of the 15th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine, 19-25 May 2007. Berkley, Calif: ISMRM Press; 2007.
Benzinger TLS, Cross A, Xu J, Naismith R, Sun S-W, Song S-K. Directional diffusivity as a magnetic resonance (MR) biomarker in demyelinating disease. Proc SPIE. 2007;6759:1-10.
Benzinger TLS. Radiologic approach to Alzheimer`s disease and other dementias: the emerging role of diffusion tensor imaging. Appl Radiol. 2005; Jan(suppl):S25-S33.
Benzinger TLS, Gregory DM, Burkoth TS, et al. The two-dimensional structure of the beta-amyloid fibril. Biochemistry. 2000;39:3491-3499.
Benzinger TLS, Gregory DM, Burkoth TS, et al. Propagating structure of Alzheimer`s beta-amyloid(10-35) is parallel beta-sheet with residues in exact register. Proc Natl Acad Sci U S A. 1998;95:13407-13412.
Last Updated: 10/15/2014 11:18:19 AM
Beta-amyloid deposition in pre-symptomatic and symptomatic carriers of Alzheimer`s disease-causing gene mutations.