Luis F.Z. Batista, Ph.D.

Assistant Professor
Internal Medicine
Hematology
Developmental Biology

Molecular Cell Biology Program
Developmental, Regenerative and Stem Cell Biology Program
Molecular Genetics and Genomics Program

  • 314-362-8816

  • 314-362-8884

  • 314 362-8826

  • 8125

  • CSRB 8816

  • LBATISTA@WUSTL.EDU

  • stem cells; iPS cells; telomerase; DNA repair; DNA damage; tissue dysfunction; telomeres

  • Understanding the importance of telomerase in human stem and progenitor cell function and regulation

Research Abstract:

The overarching goal of my research is to understand the importance of telomerase in human stem and progenitor cell function and regulation. I am interested in understanding how genetic instability leads to diminished pluripotent cell function over time and how it influences tissue homeostasis, human aging and cancer. My laboratory uses genome-wide methods to uncover alterations that drive cellular failure upon critical telomere dysfunction, using human pluripotent cells as a primary model. We combine in vitro biochemical and mechanistic studies with our ability to generate and differentiate pluripotent cells to better understand the importance of telomere maintenance in this process and to determine the events that lead from telomere dysfunction to human disease.

Selected Publications:

Batista LF (2014). Telomere biology in stem cells and reprogramming. Progress in Molecular Biology and Translational Science. Volume 125, Telomeres in health and disease, 67 – 88.

Batista LF and Artandi SE (2013). Understanding telomere diseases through analysis of patient-derived iPS cells. Current Opinion in Genetics & Development, 23, 526-533.

Zhong FL, Batista LF, Freund A, Pech MF, Venteicher AS, Artandi SE (2012). TPP1 OB-Fold Domain Controls Telomere Maintenance by Recruiting Telomerase to Chromosome Ends. Cell 150, 481–94.

Batista LF, Pech MF, Zhong FL, Nguyen HN, Xie KT, Zaug AJ, Crary SM, Choi J, Sebastiano V, Cherry A, Giri N, Wernig M, Alter BP, Cech TR, Savage SA, Reijo Pera R and Artandi SE (2011). Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells. Nature 474, 399-402.

Sebastiano V, Maeder ML, Angstman JF, Haddad B, Khayter C, Yeo DT, Goodwin MJ, Hawkins JS, Dahlborg EJ, Ramirez CL, Reyon D, Batista LF, Artandi SE, Wernig M & Joung JK (2011) In Situ Genetic Correction of the Sickle Cell Anemia Mutation in Human Induced Pluripotent Stem Cells Using Engineered Zinc Finger Nucleases. Stem Cells, 29, 1717-26.

Batista LF and Artandi SE (2009) Telomere uncapping, chromosomes, and carcinomas. Cancer Cell 15, 455-7.

Last Updated: 7/29/2014 10:49:21 AM

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