Luis F.Z. Batista, Ph.D.

Associate Professor
Internal Medicine
Hematology
Developmental Biology

Molecular Cell Biology Program
Cancer Biology Program
Developmental, Regenerative and Stem Cell Biology Program
Molecular Genetics and Genomics Program

  • 314-362-8816

  • 314-362-8884

  • 314 362-8826

  • CSRB 8816/CSRB 8817

  • LBATISTA@WUSTL.EDU

  • www.batistalab.org

  • DNA damage; DNA repair; Telomerase; Stem cell biology; Cancer; Aging

  • Understanding the role of DNA damage and RNA degradation during tissue homeostasis, regeneration, aging, and cancer

Research Abstract:

The overarching goal of our research is to understand the function of DNA damage and repair,  in tissue fitness, disease, and cancer. Our laboratory uses genome-wide methods to uncover alterations that drive cellular failure upon critical telomerase failure, nucleosome dysfunction, and DNA damage accumulation using human pluripotent stem cells as a primary model. We combine biochemical and mechanistic studies with our ability to generate and differentiate pluripotent cells towards different fates, including hematopoietic lineages and hepatocytes, to better understand the importance of of these processes in tissue homeostasis. This platform allows us to determine the events that lead from accumulation of genomic abnormalities to disease and cancer in humans.

Selected Publications:

Vessoni AT, Zhang T, Quinet A, Jeong HC, Munroe M, Wood M, Tedone E, Vindigni A, Shay JW, Greenberg RA, Batista LF (2021). Telomere erosion in human pluripotent stem cells leads to ATR-mediated mitotic catastrophe. Journal of Cell Biology (in press). 
Munroe M, Niero EL, Fok WC, Vessoni AT, Jeong H, Brenner KA and Batista LF (2020). Telomere dysfunction activates p53 and represses HNF4a expression leading to impaired human hepatocyte development and function. Hepatology; 72(4):1412-1429. 
Shukla S, Jeong H, Sturgeon CM, Parker R and Batista LF (2020). Chemical inhibition of PAPD5/7 rescues telomerase function and hematopoiesis in dyskeratosis congenita. Blood Advances, 4(12):2717-2722. 
Fok WC, Shukla S, Vessoni AT, Brenner KA, Parker R, Sturgeon CM and Batista LF (2019). Posttranscriptional regulation of TERC by PAPD5 inhibition rescues hematopoietic development in dyskeratosis congenita. Blood,133(12): 1308-1312. 
Brestoff JR, Vessoni AT, Brenner KA, [...] Batista LF (2018). Acute graft-versus-host disease following lung transplantation in a patient with a novel TERT mutation. Thorax, 73(5): 489-492.

Batista LF and Artandi SE (2013). Understanding telomere diseases through analysis of patient-derived iPS cells. Current Opinion in Genetics & Development, 23, 526-533. 
Batista LF, Pech MF, Zhong FL, Nguyen HN, Xie KT, Zaug AJ, Crary SM, Choi J, Sebastiano V, Cherry A, Giri N, Wernig M, Alter BP, Cech TR, Savage SA, Reijo Pera R and Artandi SE (2011). Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells. Nature 474, 399-402

Last Updated: 4/16/2021 1:40:03 PM

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